Comput. Biol. Med. - Simulating a dual-array electrode configuration to investigate the influence of skeletal muscle fatigue following functional electrical stimulation.

Tópicos

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Resumo

A novel, anatomically-accurate model of a tibialis anterior muscle is used to investigate the electro-physiological properties of denervated muscles following functional electrical stimulation. The model includes a state-of-the-art description of cell electro-physiology. The main objective of this work is to develop a computational framework capable of predicting the effects of different stimulation trains and electrode configurations on the excitability and fatigue of skeletal muscle tissue. Utilizing a reduced but computationally amenable model, the effects of different electrode sizes and inter-electrode distances on the number of activated muscle fibers are investigated and qualitatively compared to existing literature. To analyze muscle fatigue, the sodium current, specifically the K+ ion concentrations within the t-tubule and the calcium release from the sarcoplasmic reticulum, is used to quantify membrane and metabolic fatigue. The simulations demonstrate that lower stimulation frequencies and biphasic pulse waveforms cause less fatigue than higher stimulation frequencies and monophasic pulses. A comparison between single and dual electrode configurations (with the same overall stimulation surface) is presented to locally investigate the differences in muscle fatigue. The dual electrode configuration causes the muscle tissue to fatigue quicker.

Resumo Limpo

novel anatomicallyaccur model tibiali anterior muscl use investig electrophysiolog properti denerv muscl follow function electr stimul model includ stateoftheart descript cell electrophysiolog main object work develop comput framework capabl predict effect differ stimul train electrod configur excit fatigu skelet muscl tissu util reduc comput amen model effect differ electrod size interelectrod distanc number activ muscl fiber investig qualit compar exist literatur analyz muscl fatigu sodium current specif k ion concentr within ttubul calcium releas sarcoplasm reticulum use quantifi membran metabol fatigu simul demonstr lower stimul frequenc biphas puls waveform caus less fatigu higher stimul frequenc monophas puls comparison singl dual electrod configur overal stimul surfac present local investig differ muscl fatigu dual electrod configur caus muscl tissu fatigu quicker

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