AMIA Annu Symp Proc - Ontological approach for safe and effective polypharmacy prescription.

Tópicos

{ medic(1828) order(1363) alert(1069) }
{ concept(1167) ontolog(924) domain(897) }
{ model(3404) distribut(989) bayesian(671) }
{ implement(1333) system(1263) develop(1122) }
{ high(1669) rate(1365) level(1280) }
{ general(901) number(790) one(736) }
{ studi(1119) effect(1106) posit(819) }
{ can(774) often(719) complex(702) }
{ framework(1458) process(801) describ(734) }
{ search(2224) databas(1162) retriev(909) }
{ research(1085) discuss(1038) issu(1018) }
{ visual(1396) interact(850) tool(830) }
{ cancer(2502) breast(956) screen(824) }
{ decis(3086) make(1611) patient(1517) }
{ studi(2440) review(1878) systemat(933) }
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{ treatment(1704) effect(941) patient(846) }
{ clinic(1479) use(1117) guidelin(835) }
{ design(1359) user(1324) use(1319) }
{ care(1570) inform(1187) nurs(1089) }
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{ health(3367) inform(1360) care(1135) }
{ state(1844) use(1261) util(961) }
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{ data(3008) multipl(1320) sourc(1022) }
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{ use(2086) technolog(871) perceiv(783) }
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{ data(1737) use(1416) pattern(1282) }
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{ imag(2675) segment(2577) method(1081) }
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{ assess(1506) score(1403) qualiti(1306) }
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{ data(1714) softwar(1251) tool(1186) }
{ control(1307) perform(991) simul(935) }
{ model(2220) cell(1177) simul(1124) }
{ featur(1941) imag(1645) propos(1176) }
{ case(1353) use(1143) diagnosi(1136) }
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{ data(3963) clinic(1234) research(1004) }
{ studi(1410) differ(1259) use(1210) }
{ risk(3053) factor(974) diseas(938) }
{ perform(999) metric(946) measur(919) }
{ system(1050) medic(1026) inform(1018) }
{ model(2341) predict(2261) use(1141) }
{ compound(1573) activ(1297) structur(1058) }
{ perform(1367) use(1326) method(1137) }
{ blood(1257) pressur(1144) flow(957) }
{ spatial(1525) area(1432) region(1030) }
{ record(1888) medic(1808) patient(1693) }
{ model(3480) simul(1196) paramet(876) }
{ monitor(1329) mobil(1314) devic(1160) }
{ ehr(2073) health(1662) electron(1139) }
{ research(1218) medic(880) student(794) }
{ patient(2837) hospit(1953) medic(668) }
{ data(2317) use(1299) case(1017) }
{ age(1611) year(1155) adult(843) }
{ signal(2180) analysi(812) frequenc(800) }
{ group(2977) signific(1463) compar(1072) }
{ sampl(1606) size(1419) use(1276) }
{ gene(2352) biolog(1181) express(1162) }
{ first(2504) two(1366) second(1323) }
{ intervent(3218) particip(2042) group(1664) }
{ activ(1138) subject(705) human(624) }
{ time(1939) patient(1703) rate(768) }
{ can(981) present(881) function(850) }
{ analysi(2126) use(1163) compon(1037) }
{ health(1844) social(1437) communiti(874) }
{ structur(1116) can(940) graph(676) }
{ use(976) code(926) identifi(902) }
{ use(1733) differ(960) four(931) }
{ drug(1928) target(777) effect(648) }
{ survey(1388) particip(1329) question(1065) }
{ estim(2440) model(1874) function(577) }
{ process(1125) use(805) approach(778) }
{ activ(1452) weight(1219) physic(1104) }
{ method(1969) cluster(1462) data(1082) }
{ method(2212) result(1239) propos(1039) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

The intake of multiple medications in patients with various medical conditions challenges the delivery of medical care. Initial empirical studies and pilot implementations seem to indicate that generic safe and effective multi-drug prescription principles could be defined and reused to reduce adverse drug events and to support compliance with medical guidelines and drug formularies. Given that ontologies are known to provide well-principled, sharable, setting-independent and machine-interpretable declarative specification frameworks for modeling and reasoning on biomedical problems, we explore here their use in the context of multi-drug prescription. We propose an ontology for modeling drug-related knowledge and a repository of safe and effective generic prescription principles. To test the usability and the level of granularity of the developed ontology-based specification models and heuristic we implemented a tool that computes the complexity of multi-drug treatments, and a decision aid to check the safeness and effectiveness of prescribed multi-drug treatments.

Resumo Limpo

intak multipl medic patient various medic condit challeng deliveri medic care initi empir studi pilot implement seem indic generic safe effect multidrug prescript principl defin reus reduc advers drug event support complianc medic guidelin drug formulari given ontolog known provid wellprincipl sharabl settingindepend machineinterpret declar specif framework model reason biomed problem explor use context multidrug prescript propos ontolog model drugrel knowledg repositori safe effect generic prescript principl test usabl level granular develop ontologybas specif model heurist implement tool comput complex multidrug treatment decis aid check safe effect prescrib multidrug treatment

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