IEEE J Biomed Health Inform - Red blood cell cluster separation from digital images for use in sickle cell disease.

Tópicos

{ method(1969) cluster(1462) data(1082) }
{ use(1733) differ(960) four(931) }
{ imag(2675) segment(2577) method(1081) }
{ gene(2352) biolog(1181) express(1162) }
{ detect(2391) sensit(1101) algorithm(908) }
{ method(2212) result(1239) propos(1039) }
{ estim(2440) model(1874) function(577) }
{ take(945) account(800) differ(722) }
{ method(984) reconstruct(947) comput(926) }
{ blood(1257) pressur(1144) flow(957) }
{ result(1111) use(1088) new(759) }
{ patient(2315) diseas(1263) diabet(1191) }
{ use(976) code(926) identifi(902) }
{ method(1219) similar(1157) match(930) }
{ featur(3375) classif(2383) classifi(1994) }
{ network(2748) neural(1063) input(814) }
{ data(3963) clinic(1234) research(1004) }
{ activ(1138) subject(705) human(624) }
{ imag(1947) propos(1133) code(1026) }
{ imag(1057) registr(996) error(939) }
{ imag(2830) propos(1344) filter(1198) }
{ problem(2511) optim(1539) algorithm(950) }
{ extract(1171) text(1153) clinic(932) }
{ control(1307) perform(991) simul(935) }
{ featur(1941) imag(1645) propos(1176) }
{ perform(999) metric(946) measur(919) }
{ visual(1396) interact(850) tool(830) }
{ model(2656) set(1616) predict(1553) }
{ data(2317) use(1299) case(1017) }
{ group(2977) signific(1463) compar(1072) }
{ sampl(1606) size(1419) use(1276) }
{ first(2504) two(1366) second(1323) }
{ can(981) present(881) function(850) }
{ high(1669) rate(1365) level(1280) }
{ cancer(2502) breast(956) screen(824) }
{ model(3404) distribut(989) bayesian(671) }
{ can(774) often(719) complex(702) }
{ data(1737) use(1416) pattern(1282) }
{ inform(2794) health(2639) internet(1427) }
{ system(1976) rule(880) can(841) }
{ measur(2081) correl(1212) valu(896) }
{ bind(1733) structur(1185) ligand(1036) }
{ sequenc(1873) structur(1644) protein(1328) }
{ studi(2440) review(1878) systemat(933) }
{ motion(1329) object(1292) video(1091) }
{ assess(1506) score(1403) qualiti(1306) }
{ treatment(1704) effect(941) patient(846) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ framework(1458) process(801) describ(734) }
{ error(1145) method(1030) estim(1020) }
{ chang(1828) time(1643) increas(1301) }
{ learn(2355) train(1041) set(1003) }
{ concept(1167) ontolog(924) domain(897) }
{ clinic(1479) use(1117) guidelin(835) }
{ algorithm(1844) comput(1787) effici(935) }
{ method(1557) propos(1049) approach(1037) }
{ data(1714) softwar(1251) tool(1186) }
{ design(1359) user(1324) use(1319) }
{ model(2220) cell(1177) simul(1124) }
{ care(1570) inform(1187) nurs(1089) }
{ general(901) number(790) one(736) }
{ search(2224) databas(1162) retriev(909) }
{ case(1353) use(1143) diagnosi(1136) }
{ howev(809) still(633) remain(590) }
{ studi(1410) differ(1259) use(1210) }
{ risk(3053) factor(974) diseas(938) }
{ research(1085) discuss(1038) issu(1018) }
{ system(1050) medic(1026) inform(1018) }
{ import(1318) role(1303) understand(862) }
{ model(2341) predict(2261) use(1141) }
{ compound(1573) activ(1297) structur(1058) }
{ perform(1367) use(1326) method(1137) }
{ studi(1119) effect(1106) posit(819) }
{ spatial(1525) area(1432) region(1030) }
{ record(1888) medic(1808) patient(1693) }
{ health(3367) inform(1360) care(1135) }
{ model(3480) simul(1196) paramet(876) }
{ monitor(1329) mobil(1314) devic(1160) }
{ ehr(2073) health(1662) electron(1139) }
{ state(1844) use(1261) util(961) }
{ research(1218) medic(880) student(794) }
{ patient(2837) hospit(1953) medic(668) }
{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ signal(2180) analysi(812) frequenc(800) }
{ cost(1906) reduc(1198) effect(832) }
{ data(3008) multipl(1320) sourc(1022) }
{ intervent(3218) particip(2042) group(1664) }
{ time(1939) patient(1703) rate(768) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ analysi(2126) use(1163) compon(1037) }
{ health(1844) social(1437) communiti(874) }
{ structur(1116) can(940) graph(676) }
{ drug(1928) target(777) effect(648) }
{ implement(1333) system(1263) develop(1122) }
{ survey(1388) particip(1329) question(1065) }
{ decis(3086) make(1611) patient(1517) }
{ process(1125) use(805) approach(778) }
{ activ(1452) weight(1219) physic(1104) }

Resumo

The study of cell morphology is an important aspect of the diagnosis of some diseases, such as sickle cell disease, because red blood cell deformation is caused by these diseases. Due to the elongated shape of the erythrocyte, ellipse adjustment and concave point detection are applied widely to images of peripheral blood samples, including during the detection of cells that are partially occluded in the clusters generated by the sample preparation process. In the present study, we propose a method for the analysis of the shape of erythrocytes in peripheral blood smear samples of sickle cell disease, which uses ellipse adjustments and a new algorithm for detecting notable points. Furthermore, we apply a set of constraints that allow the elimination of significant image preprocessing steps proposed in previous studies. We used three types of images to validate our method: artificial images, which were automatically generated in a random manner using a computer code; real images from peripheral blood smear sample images that contained normal and elongated erythrocytes; and synthetic images generated from real isolated cells. Using the proposed method, the efficiency of detecting the two types of objects in the three image types exceeded 99.00%, 98.00%, and 99.35%, respectively. These efficiency levels were superior to the results obtained with previously proposed methods using the same database, which is available at http://erythrocytesidb.uib.es/. This method can be extended to clusters of several cells and it requires no user inputs.

Resumo Limpo

studi cell morpholog import aspect diagnosi diseas sickl cell diseas red blood cell deform caus diseas due elong shape erythrocyt ellips adjust concav point detect appli wide imag peripher blood sampl includ detect cell partial occlud cluster generat sampl prepar process present studi propos method analysi shape erythrocyt peripher blood smear sampl sickl cell diseas use ellips adjust new algorithm detect notabl point furthermor appli set constraint allow elimin signific imag preprocess step propos previous studi use three type imag valid method artifici imag automat generat random manner use comput code real imag peripher blood smear sampl imag contain normal elong erythrocyt synthet imag generat real isol cell use propos method effici detect two type object three imag type exceed respect effici level superior result obtain previous propos method use databas avail httperythrocytesidbuib method can extend cluster sever cell requir user input

Resumos Similares

Int J Health Geogr - Detection of clusters of a rare disease over a large territory: performance of cluster detection methods. ( 0,728058677081824 )
J. Comput. Biol. - Biological cluster evaluation for gene function prediction. ( 0,707101858741421 )
Comput Methods Programs Biomed - Systematic method to assess microvascular recruitment using contrast-enhanced ultrasound. Application to insulin-induced capillary recruitment in subjects with T1DM. ( 0,695792576032075 )
Comput. Biol. Med. - CAM: a web tool for combining array CGH and microarray gene expression data from multiple samples. ( 0,693538831379283 )
Int J Comput Assist Radiol Surg - Fast lung nodule detection in chest CT images using cylindrical nodule-enhancement filter. ( 0,674838212497902 )
J Biomed Inform - Average correlation clustering algorithm (ACCA) for grouping of co-regulated genes with similar pattern of variation in their expression values. ( 0,673553150764695 )
Brief. Bioinformatics - Similarity of markers identified from cancer gene expression studies: observations from GEO. ( 0,666272219763048 )
Comput Math Methods Med - A wavelet relational fuzzy C-means algorithm for 2D gel image segmentation. ( 0,650409439577224 )
Int J Health Geogr - Detection of arbitrarily-shaped clusters using a neighbor-expanding approach: a case study on murine typhus in south Texas. ( 0,650164182877082 )
J Integr Bioinform - Clustering of gene expression profiles: creating initialization-independent clusterings by eliminating unstable genes. ( 0,648401798437456 )
J Biomed Inform - Extension of the survival dimensionality reduction algorithm to detect epistasis in competing risks models (SDR-CR). ( 0,647075632767011 )
AMIA Annu Symp Proc - Automatic selection of preprocessing methods for improving predictions on mass spectrometry protein profiles. ( 0,642756247126653 )
Comput Math Methods Med - Liver segmentation based on Snakes Model and improved GrowCut algorithm in abdominal CT image. ( 0,641035226101537 )
Comput. Aided Surg. - The Equidistant Method - a novel hip joint simulation algorithm for detection of femoroacetabular impingement. ( 0,637083457299738 )
Brief. Bioinformatics - GO-function: deriving biologically relevant functions from statistically significant functions. ( 0,634405300632085 )
IEEE Trans Pattern Anal Mach Intell - A Link-Based Approach to the Cluster Ensemble Problem. ( 0,632818685382507 )
Int J Health Geogr - A binary-based approach for detecting irregularly shaped clusters. ( 0,631676442983222 )
Comput Methods Programs Biomed - Generalized rough fuzzy c-means algorithm for brain MR image segmentation. ( 0,623353260187072 )
IEEE Trans Neural Netw Learn Syst - Improved Fault Classification in Series Compensated Transmission Line: Comparative Evaluation of Chebyshev Neural Network Training Algorithms. ( 0,621009099618588 )
Int J Health Geogr - Using statistical methods and genotyping to detect tuberculosis outbreaks. ( 0,61879636983703 )
Neural Comput - Spontaneous clustering via minimum -divergence. ( 0,617313913589178 )
J Chem Inf Model - Comparison of combinatorial clustering methods on pharmacological data sets represented by machine learning-selected real molecular descriptors. ( 0,616304591597033 )
AMIA Annu Symp Proc - Using hierarchical mixture of experts model for fusion of outbreak detection methods. ( 0,614723202250098 )
Int J Comput Assist Radiol Surg - A Hessian-based filter for vascular segmentation of noisy hepatic CT scans. ( 0,612251993915352 )
Comput Biol Chem - Fast detection of high-order epistatic interactions in genome-wide association studies using information theoretic measure. ( 0,609647795721702 )
Comput Methods Programs Biomed - Robust information gain based fuzzy c-means clustering and classification of carotid artery ultrasound images. ( 0,606197847390395 )
Comput. Biol. Med. - Analysis of adductors angle measurement in Hammersmith infant neurological examinations using mean shift segmentation and feature point based object tracking. ( 0,605646072749838 )
Int J Health Geogr - Detecting activity locations from raw GPS data: a novel kernel-based algorithm. ( 0,604904842600181 )
Comput Math Methods Med - Decimative spectral estimation with unconstrained model order. ( 0,60299832607897 )
Comput Biol Chem - Meta-analysis of microarray data: The case of imatinib resistance in chronic myelogenous leukemia. ( 0,602845290907844 )
Med Decis Making - Developing appropriate methods for cost-effectiveness analysis of cluster randomized trials. ( 0,600623429293227 )
Int J Neural Syst - A genetic graph-based approach for partitional clustering. ( 0,596302710942121 )
J. Comput. Biol. - Markov logic networks in the analysis of genetic data. ( 0,595352553098059 )
J Am Med Inform Assoc - Integrated morphologic analysis for the identification and characterization of disease subtypes. ( 0,593363769933295 )
Neural Comput - A nonparametric clustering algorithm with a quantile-based likelihood estimator. ( 0,590069907428682 )
Comput. Biol. Med. - Nonlinear dimensionality reduction of gene expression data for visualization and clustering analysis of cancer tissue samples. ( 0,588027535671758 )
Comput. Biol. Med. - Multi-stage filtering for improving confidence level and determining dominant clusters in clustering algorithms of gene expression data. ( 0,58784587933626 )
J Biomed Inform - Statistical file matching of flow cytometry data. ( 0,586820955996839 )
Spat Spatiotemporal Epidemiol - Optimal selection of the spatial scan parameters for cluster detection: a simulation study. ( 0,585721163790131 )
Brief. Bioinformatics - Accounting for noise when clustering biological data. ( 0,585600540521926 )
Comput Methods Programs Biomed - Simple methods for segmentation and measurement of diabetic retinopathy lesions in retinal fundus images. ( 0,583373445538982 )
J Chem Inf Model - Metabolism site prediction based on xenobiotic structural formulas and PASS prediction algorithm. ( 0,583350861114871 )
Comput Methods Programs Biomed - Fuzzy and hard clustering analysis for thyroid disease. ( 0,580573555673474 )
Comput Math Methods Med - Ultrasound common carotid artery segmentation based on active shape model. ( 0,577054419685604 )
Med Decis Making - Multiple imputation methods for handling missing data in cost-effectiveness analyses that use data from hierarchical studies: an application to cluster randomized trials. ( 0,575726484589781 )
IEEE Trans Image Process - A level set method for image segmentation in the presence of intensity inhomogeneities with application to MRI. ( 0,57407277704998 )
IEEE J Biomed Health Inform - A multistaged automatic restoration of noisy microscopy cell images. ( 0,573310467978314 )
Comput Biol Chem - Mode of action classification of chemicals using multi-concentration time-dependent cellular response profiles. ( 0,568437899683039 )
J Integr Bioinform - An evolutionary and visual framework for clustering of DNA microarray data. ( 0,568040302416814 )
Spat Spatiotemporal Epidemiol - Performance of cancer cluster Q-statistics for case-control residential histories. ( 0,566963228699448 )
Comput Methods Programs Biomed - Automatic classification of left ventricular wall segments in small animal ultrasound imaging. ( 0,566328127779078 )
Artif Intell Med - Identifying a small set of marker genes using minimum expected cost of misclassification. ( 0,56439937544225 )
J Am Med Inform Assoc - Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study. ( 0,56271717904069 )
Comput. Biol. Med. - Finding multivariate outliers in fMRI time-series data. ( 0,562449620580557 )
Brief. Bioinformatics - A large-scale benchmark study of existing algorithms for taxonomy-independent microbial community analysis. ( 0,561308086483157 )
Comput. Aided Surg. - A hybrid method based on level set and 3D region growing for segmentation of the thoracic aorta. ( 0,560685874815575 )
Brief. Bioinformatics - Data construction for phosphorylation site prediction. ( 0,559660879105282 )
IEEE Trans Vis Comput Graph - GPU-based Multilevel Clustering. ( 0,557687533136061 )
Comput Methods Programs Biomed - Efficient inhomogeneity compensation using fuzzy c-means clustering models. ( 0,556876338646654 )
Int J Comput Assist Radiol Surg - Rapid image recognition of body parts scanned in computed tomography datasets. ( 0,552873950480717 )
J Chem Inf Model - Investigation of the use of spectral clustering for the analysis of molecular data. ( 0,551785122989059 )
Sci Data - Assessment of lipidomic species in hepatocyte lipid droplets from stressed mouse models. ( 0,551459437870004 )
Comput Methods Programs Biomed - fMRI analysis on the GPU-possibilities and challenges. ( 0,551194816207325 )
J. Comput. Biol. - A geometric clustering algorithm with applications to structural data. ( 0,548315033237669 )
Int J Neural Syst - A cluster merging method for time series microarray with production values. ( 0,547283501276286 )
Comput Math Methods Med - A robust rerank approach for feature selection and its application to pooling-based GWA studies. ( 0,54692198817471 )
Int J Neural Syst - Adaptive k-means algorithm for overlapped graph clustering. ( 0,546106613998735 )
J Med Syst - Application of attribute weighting method based on clustering centers to discrimination of linearly non-separable medical datasets. ( 0,54584462482917 )
Comput Methods Programs Biomed - Automated detection of endotracheal tubes in paediatric chest radiographs. ( 0,545211974887727 )
Med Biol Eng Comput - Performance assessment of isolation methods for geometrical cerebral aneurysm analysis. ( 0,544873271623116 )
IEEE Trans Image Process - Contrast-independent curvilinear structure detection in biomedical images. ( 0,54402347234429 )
IEEE J Biomed Health Inform - Laryngeal Tumor Detection and Classification in Endoscopic Video. ( 0,543527060495126 )
Comput. Biol. Med. - Unsupervised tumour segmentation in PET using local and global intensity-fitting active surface and alpha matting. ( 0,541722151632594 )
Comput Methods Programs Biomed - Automatic selection of arterial input function on dynamic contrast-enhanced MR images. ( 0,541045128565506 )
BMC Med Inform Decis Mak - Efficient algorithms for fast integration on large data sets from multiple sources. ( 0,540545689133793 )
IEEE Trans Image Process - Natural image segmentation based on tree equipartition, Bayesian flooding and region merging. ( 0,535346318902358 )
AMIA Annu Symp Proc - A fast algorithm for learning epistatic genomic relationships. ( 0,535103250969141 )
Comput Biol Chem - Ped_Outlier software for automatic identification of within-family outliers. ( 0,533719680503443 )
Comput Biol Chem - Using volcano plots and regularized-chi statistics in genetic association studies. ( 0,532648521369757 )
IEEE Trans Image Process - Evaluating combinational illumination estimation methods on real-world images. ( 0,530904019025811 )
Comput Methods Programs Biomed - Automatic segmentation of corpus callosum using Gaussian mixture modeling and Fuzzy C means methods. ( 0,529179996344787 )
J Integr Bioinform - Profiling of genetic switches using boolean implications in expression data. ( 0,526748462083842 )
Brief. Bioinformatics - Comparative analysis of methods for identifying somatic copy number alterations from deep sequencing data. ( 0,526438726062476 )
J. Comput. Biol. - EDAR: an efficient error detection and removal algorithm for next generation sequencing data. ( 0,525783895058242 )
Comput Methods Programs Biomed - A state of the art review on intima-media thickness (IMT) measurement and wall segmentation techniques for carotid ultrasound. ( 0,524831724120794 )
Comput Methods Programs Biomed - Automatic model-based tracing algorithm for vessel segmentation and diameter estimation. ( 0,524454315096899 )
Int J Comput Assist Radiol Surg - Computer-aided nidus segmentation and angiographic characterization of arteriovenous malformations. ( 0,524333230868017 )
Comput. Biol. Med. - A straightforward approach to computer-aided polyp detection using a polyp-specific volumetric feature in CT colonography. ( 0,523637315396484 )
Med Decis Making - Cost-saving tree-structured survival analysis for hip fracture of study of osteoporotic fractures data. ( 0,523637315396484 )
Int J Comput Assist Radiol Surg - An algorithm for calculi segmentation on ureteroscopic images. ( 0,522573439001017 )
Comput Biol Chem - piClust: a density based piRNA clustering algorithm. ( 0,52254361700486 )
IEEE Trans Pattern Anal Mach Intell - Paired Regions for Shadow Detection and Removal. ( 0,522193736152516 )
IEEE Trans Pattern Anal Mach Intell - Semi-Supervised Kernel Mean Shift Clustering. ( 0,521537070351587 )
Comput Math Methods Med - White blood cell segmentation by circle detection using electromagnetism-like optimization. ( 0,520974748941223 )
Int J Health Geogr - Spatial heterogeneity of type I error for local cluster detection tests. ( 0,519650075866878 )
J Biomed Inform - Enabling enrichment analysis with the Human Disease Ontology. ( 0,518698214684937 )
Med Biol Eng Comput - Automated segmentation of comet assay images using Gaussian filtering and fuzzy clustering. ( 0,516489722480806 )
Int J Comput Assist Radiol Surg - Automatic lung segmentation method for MRI-based lung perfusion studies of patients with chronic obstructive pulmonary disease. ( 0,516325485250724 )
Comput Methods Programs Biomed - Gold-standard and improved framework for sperm head segmentation. ( 0,516184781409524 )
Artif Intell Med - Hybrid genetic algorithm-neural network: feature extraction for unpreprocessed microarray data. ( 0,516120228723635 )