IEEE J Biomed Health Inform - Analysis of protein interaction networks for the detection of candidate hepatitis B and C biomarkers.

Tópicos

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Resumo

Hepatitis B virus (HBV) and hepatitis C virus (HCV) infection are the major causes of chronic liver disease, cirrhosis and hepatocellular carcinoma (HCC). The resolution or chronicity of acute infection is dependent on a complex interplay between virus and innate/adaptive immunity. The mechanisms that lead a significant proportion of patients to more severe liver disease are not clearly defined and involve virus induced host gene/protein alterations. The utilization of protein interaction networks (PINs) is expected to identify novel aspects of the disease concerning the patients' immune response to virus as well as the main pathways that are involved in the development of fibrosis and HCC. In this study, we designed several PINs for HBV and HCV and employed topological, modular, and functional analysis techniques in order to determine significant network nodes that correspond to prominent candidate biomarkers. The networks were built using data from various interaction databases. When the overall PINs of HBV and HCV were compared, 48 nodes were found in common. The implementation of a statistical ranking procedure indicated that three of them are of higher importance.

Resumo Limpo

hepat b virus hbv hepat c virus hcv infect major caus chronic liver diseas cirrhosi hepatocellular carcinoma hcc resolut chronic acut infect depend complex interplay virus innateadapt immun mechan lead signific proport patient sever liver diseas clear defin involv virus induc host geneprotein alter util protein interact network pin expect identifi novel aspect diseas concern patient immun respons virus well main pathway involv develop fibrosi hcc studi design sever pin hbv hcv employ topolog modular function analysi techniqu order determin signific network node correspond promin candid biomark network built use data various interact databas overal pin hbv hcv compar node found common implement statist rank procedur indic three higher import

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