IEEE J Biomed Health Inform - Experimental investigation of the influence of the aortic stiffness on hemodynamics in the ascending aorta.

Tópicos

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Resumo

A three-dimensional (3-D) pulsatile aortic flow in a human ascending aorta is studied to investigate the effect of the aortic stiffness on the flow field and turbulent fluctuating velocities in the ascending aorta. A nonintrusive optical measurement technique, 3-D particle tracking velocimetry (3D-PTV), has been applied to anatomically accurate phantoms under clinically realistic conditions. A compliant silicon phantom was used to mimic the healthy aorta, and a rigid model was used to imitate the pathological case that appears in aortas for example as a result of aging. The realistic models are transparent which allows optical access to the investigation domain, and the index of refraction was matched to avoid optical distortions. Our results revealed that the aortic stiffness leads to an increase in systolic velocity and a decrease in the Windkessel effect, which is associated with the diastolic blood pressure. Furthermore, we found that the turbulent kinetic energy is about an order of magnitude higher for the rigid aorta, that is, an increase in aortic stiffness increases the magnitude of turbulent fluctuating velocities. The spatial distribution of the flow velocity showed that the flow is more organized and coherent spiraling patterns develop for the compliant aorta which helps to dampen the influence of disturbed flow. Finally, we observed higher Lagrangian acceleration and hence higher instantaneous forces acting on blood particles in the stiff case which implies that aging and hence arterial stiffening provokes distinctive alterations in blood flow, and these alterations may cause pathological symptoms in the cardiovascular system.

Resumo Limpo

threedimension d pulsatil aortic flow human ascend aorta studi investig effect aortic stiff flow field turbul fluctuat veloc ascend aorta nonintrus optic measur techniqu d particl track velocimetri dptv appli anatom accur phantom clinic realist condit compliant silicon phantom use mimic healthi aorta rigid model use imit patholog case appear aorta exampl result age realist model transpar allow optic access investig domain index refract match avoid optic distort result reveal aortic stiff lead increas systol veloc decreas windkessel effect associ diastol blood pressur furthermor found turbul kinet energi order magnitud higher rigid aorta increas aortic stiff increas magnitud turbul fluctuat veloc spatial distribut flow veloc show flow organ coher spiral pattern develop compliant aorta help dampen influenc disturb flow final observ higher lagrangian acceler henc higher instantan forc act blood particl stiff case impli age henc arteri stiffen provok distinct alter blood flow alter may caus patholog symptom cardiovascular system

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