AMIA Annu Symp Proc - Semantic processing to identify adverse drug event information from black box warnings.

Tópicos

{ extract(1171) text(1153) clinic(932) }
{ drug(1928) target(777) effect(648) }
{ risk(3053) factor(974) diseas(938) }
{ concept(1167) ontolog(924) domain(897) }
{ ehr(2073) health(1662) electron(1139) }
{ activ(1138) subject(705) human(624) }
{ bind(1733) structur(1185) ligand(1036) }
{ patient(2315) diseas(1263) diabet(1191) }
{ data(1714) softwar(1251) tool(1186) }
{ sampl(1606) size(1419) use(1276) }
{ implement(1333) system(1263) develop(1122) }
{ decis(3086) make(1611) patient(1517) }
{ model(3404) distribut(989) bayesian(671) }
{ can(774) often(719) complex(702) }
{ inform(2794) health(2639) internet(1427) }
{ network(2748) neural(1063) input(814) }
{ take(945) account(800) differ(722) }
{ studi(1119) effect(1106) posit(819) }
{ model(2656) set(1616) predict(1553) }
{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ group(2977) signific(1463) compar(1072) }
{ intervent(3218) particip(2042) group(1664) }
{ time(1939) patient(1703) rate(768) }
{ can(981) present(881) function(850) }
{ structur(1116) can(940) graph(676) }
{ high(1669) rate(1365) level(1280) }
{ imag(1947) propos(1133) code(1026) }
{ data(1737) use(1416) pattern(1282) }
{ system(1976) rule(880) can(841) }
{ measur(2081) correl(1212) valu(896) }
{ imag(1057) registr(996) error(939) }
{ sequenc(1873) structur(1644) protein(1328) }
{ method(1219) similar(1157) match(930) }
{ featur(3375) classif(2383) classifi(1994) }
{ imag(2830) propos(1344) filter(1198) }
{ imag(2675) segment(2577) method(1081) }
{ studi(2440) review(1878) systemat(933) }
{ motion(1329) object(1292) video(1091) }
{ assess(1506) score(1403) qualiti(1306) }
{ treatment(1704) effect(941) patient(846) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ framework(1458) process(801) describ(734) }
{ problem(2511) optim(1539) algorithm(950) }
{ error(1145) method(1030) estim(1020) }
{ chang(1828) time(1643) increas(1301) }
{ learn(2355) train(1041) set(1003) }
{ clinic(1479) use(1117) guidelin(835) }
{ algorithm(1844) comput(1787) effici(935) }
{ method(1557) propos(1049) approach(1037) }
{ design(1359) user(1324) use(1319) }
{ control(1307) perform(991) simul(935) }
{ model(2220) cell(1177) simul(1124) }
{ care(1570) inform(1187) nurs(1089) }
{ general(901) number(790) one(736) }
{ method(984) reconstruct(947) comput(926) }
{ search(2224) databas(1162) retriev(909) }
{ featur(1941) imag(1645) propos(1176) }
{ case(1353) use(1143) diagnosi(1136) }
{ howev(809) still(633) remain(590) }
{ data(3963) clinic(1234) research(1004) }
{ studi(1410) differ(1259) use(1210) }
{ perform(999) metric(946) measur(919) }
{ research(1085) discuss(1038) issu(1018) }
{ system(1050) medic(1026) inform(1018) }
{ import(1318) role(1303) understand(862) }
{ model(2341) predict(2261) use(1141) }
{ visual(1396) interact(850) tool(830) }
{ compound(1573) activ(1297) structur(1058) }
{ perform(1367) use(1326) method(1137) }
{ blood(1257) pressur(1144) flow(957) }
{ spatial(1525) area(1432) region(1030) }
{ record(1888) medic(1808) patient(1693) }
{ health(3367) inform(1360) care(1135) }
{ model(3480) simul(1196) paramet(876) }
{ monitor(1329) mobil(1314) devic(1160) }
{ state(1844) use(1261) util(961) }
{ research(1218) medic(880) student(794) }
{ patient(2837) hospit(1953) medic(668) }
{ data(2317) use(1299) case(1017) }
{ signal(2180) analysi(812) frequenc(800) }
{ cost(1906) reduc(1198) effect(832) }
{ gene(2352) biolog(1181) express(1162) }
{ data(3008) multipl(1320) sourc(1022) }
{ first(2504) two(1366) second(1323) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ analysi(2126) use(1163) compon(1037) }
{ health(1844) social(1437) communiti(874) }
{ cancer(2502) breast(956) screen(824) }
{ use(976) code(926) identifi(902) }
{ use(1733) differ(960) four(931) }
{ result(1111) use(1088) new(759) }
{ survey(1388) particip(1329) question(1065) }
{ estim(2440) model(1874) function(577) }
{ process(1125) use(805) approach(778) }
{ activ(1452) weight(1219) physic(1104) }
{ method(1969) cluster(1462) data(1082) }
{ method(2212) result(1239) propos(1039) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

Adverse drug events account for two million combined injuries, hospitalizations, or deaths each year. Furthermore, there are few comprehensive, up-to-date, and free sources of drug information. Clinical decision support systems may significantly mitigate the number of adverse drug events. However, these systems depend on up-to-date, comprehensive, and codified data to serve as input. The DailyMed website, a resource managed by the FDA and NLM, contains all currently approved drugs. We used a semantic natural language processing approach that successfully extracted information for adverse drug events, at-risk conditions, and susceptible populations from black box warning labels on this site. The precision, recall, and F-score were, 94%, 52%, 0.67 for adverse drug events; 80%, 53%, and 0.64 for conditions; and 95%, 44%, 0.61 for populations. Overall performance was 90% precision, 51% recall, and 0.65 F-Score. Information extracted can be stored in a structured format and may support clinical decision support systems.

Resumo Limpo

advers drug event account two million combin injuri hospit death year furthermor comprehens uptod free sourc drug inform clinic decis support system may signific mitig number advers drug event howev system depend uptod comprehens codifi data serv input dailym websit resourc manag fda nlm contain current approv drug use semant natur languag process approach success extract inform advers drug event atrisk condit suscept popul black box warn label site precis recal fscore advers drug event condit popul overal perform precis recal fscore inform extract can store structur format may support clinic decis support system

Resumos Similares

J Am Med Inform Assoc - Extracting drug indication information from structured product labels using natural language processing. ( 0,879341289354627 )
AMIA Annu Symp Proc - ADESSA: A Real-Time Decision Support Service for Delivery of Semantically Coded Adverse Drug Event Data. ( 0,868198624623974 )
AMIA Annu Symp Proc - Pharmacovigilance on twitter? Mining tweets for adverse drug reactions. ( 0,847204509658946 )
J Biomed Inform - Automatic signal extraction, prioritizing and filtering approaches in detecting post-marketing cardiovascular events associated with targeted cancer drugs from the FDA Adverse Event Reporting System (FAERS). ( 0,826672260469439 )
J Biomed Inform - Towards generating a patient's timeline: extracting temporal relationships from clinical notes. ( 0,811943886655263 )
Appl Clin Inform - Representation of information about family relatives as structured data in electronic health records. ( 0,806909296079988 )
J Biomed Inform - Disambiguation of PharmGKB drug-disease relations with NDF-RT and SPL. ( 0,806250712903283 )
J Am Med Inform Assoc - A hybrid system for temporal information extraction from clinical text. ( 0,803010638391352 )
AMIA Annu Symp Proc - Application of a temporal reasoning framework tool in analysis of medical device adverse events. ( 0,796754191332257 )
J Am Med Inform Assoc - Combining rules and machine learning for extraction of temporal expressions and events from clinical narratives. ( 0,794878336834006 )
BMC Med Inform Decis Mak - A pipeline to extract drug-adverse event pairs from multiple data sources. ( 0,794551857760414 )
J Biomed Inform - MedTime: a temporal information extraction system for clinical narratives. ( 0,791913267975941 )
AMIA Annu Symp Proc - Inter-annotator reliability of medical events, coreferences and temporal relations in clinical narratives by annotators with varying levels of clinical expertise. ( 0,788349831088753 )
BMC Med Inform Decis Mak - Text summarization as a decision support aid. ( 0,785691426918603 )
J Am Med Inform Assoc - Anaphoric relations in the clinical narrative: corpus creation. ( 0,78527792259409 )
J Biomed Inform - Anaphoric reference in clinical reports: characteristics of an annotated corpus. ( 0,78130232444713 )
J Am Med Inform Assoc - Knowledge-based biomedical word sense disambiguation: an evaluation and application to clinical document classification. ( 0,779946027942833 )
J Am Med Inform Assoc - An end-to-end system to identify temporal relation in discharge summaries: 2012 i2b2 challenge. ( 0,779650429834581 )
AMIA Annu Symp Proc - Semantic processing to identify adverse drug event information from black box warnings. ( 0,777311531249938 )
AMIA Annu Symp Proc - Pattern mining for extraction of mentions of Adverse Drug Reactions from user comments. ( 0,77594658406617 )
J. Med. Internet Res. - Web 2.0-based crowdsourcing for high-quality gold standard development in clinical natural language processing. ( 0,775078372388089 )
J Biomed Inform - A SNPshot of PubMed to associate genetic variants with drugs, diseases, and adverse reactions. ( 0,774588746126316 )
BMC Med Inform Decis Mak - Mining adverse drug reactions from online healthcare forums using hidden Markov model. ( 0,770679295788073 )
J Biomed Inform - Semi-automatic semantic annotation of PubMed queries: a study on quality, efficiency, satisfaction. ( 0,769616455995474 )
AMIA Annu Symp Proc - Throw the bath water out, keep the baby: keeping medically-relevant terms for text mining. ( 0,764809282117782 )
Artif Intell Med - Biomedical events extraction using the hidden vector state model. ( 0,763794456962233 )
J Am Med Inform Assoc - Assessing the role of a medication-indication resource in the treatment relation extraction from clinical text. ( 0,763665118954091 )
J Am Med Inform Assoc - Evaluating temporal relations in clinical text: 2012 i2b2 Challenge. ( 0,76245243195408 )
J Biomed Inform - A concept-driven biomedical knowledge extraction and visualization framework for conceptualization of text corpora. ( 0,761978598670022 )
J Am Med Inform Assoc - Eventual situations for timeline extraction from clinical reports. ( 0,761464073549119 )
J Am Med Inform Assoc - A sense inventory for clinical abbreviations and acronyms created using clinical notes and medical dictionary resources. ( 0,760369301665085 )
J Med Syst - Redactable signatures for signed CDA Documents. ( 0,757938464291641 )
J Biomed Inform - Evaluating the effects of machine pre-annotation and an interactive annotation interface on manual de-identification of clinical text. ( 0,757189779531931 )
J Am Med Inform Assoc - Evaluating the impact of pre-annotation on annotation speed and potential bias: natural language processing gold standard development for clinical named entity recognition in clinical trial announcements. ( 0,757164586127943 )
J Biomed Inform - Lexical patterns, features and knowledge resources for coreference resolution in clinical notes. ( 0,752906911990398 )
J Biomed Inform - Development and evaluation of RapTAT: a machine learning system for concept mapping of phrases from medical narratives. ( 0,751008576228898 )
J Biomed Inform - UMLS content views appropriate for NLP processing of the biomedical literature vs. clinical text. ( 0,750318466984193 )
J Am Med Inform Assoc - Text mining for the Vaccine Adverse Event Reporting System: medical text classification using informative feature selection. ( 0,748478205676004 )
J Chem Inf Model - Automated extraction of information on chemical-P-glycoprotein interactions from the literature. ( 0,748336541087077 )
AMIA Annu Symp Proc - Natural language processing for lines and devices in portable chest x-rays. ( 0,747989459252609 )
J Am Med Inform Assoc - Assisted annotation of medical free text using RapTAT. ( 0,74750832877552 )
J Am Med Inform Assoc - Towards comprehensive syntactic and semantic annotations of the clinical narrative. ( 0,746816573421805 )
AMIA Annu Symp Proc - Extracting Concepts Related to Homelessness from the Free Text of VA Electronic Medical Records. ( 0,745571319648855 )
J Am Med Inform Assoc - A flexible framework for recognizing events, temporal expressions, and temporal relations in clinical text. ( 0,743507259628727 )
J Am Med Inform Assoc - The effect of word familiarity on actual and perceived text difficulty. ( 0,741980638458716 )
J Biomed Inform - Identifying plausible adverse drug reactions using knowledge extracted from the literature. ( 0,73956852737672 )
J Biomed Inform - Desiderata for ontologies to be used in semantic annotation of biomedical documents. ( 0,738185246879148 )
J Am Med Inform Assoc - Automatic discourse connective detection in biomedical text. ( 0,737899903807363 )
J Biomed Inform - Extraction of events and temporal expressions from clinical narratives. ( 0,73785349493539 )
AMIA Annu Symp Proc - Building gold standard corpora for medical natural language processing tasks. ( 0,737824575775017 )
AMIA Annu Symp Proc - Extracting patient demographics and personal medical information from online health forums. ( 0,737124408534311 )
J Am Med Inform Assoc - MedXN: an open source medication extraction and normalization tool for clinical text. ( 0,736396121866708 )
J Biomed Inform - NCBI disease corpus: a resource for disease name recognition and concept normalization. ( 0,736231070666695 )
J Integr Bioinform - Automatic extraction of microorganisms and their habitats from free text using text mining workflows. ( 0,735586224955668 )
Sci Data - Building the graph of medicine from millions of clinical narratives. ( 0,734029999581105 )
Comput Methods Programs Biomed - BioAnnote: a software platform for annotating biomedical documents with application in medical learning environments. ( 0,734012723576217 )
AMIA Annu Symp Proc - TagLine: Information Extraction for Semi-Structured Text in Medical Progress Notes. ( 0,731471839762913 )
AMIA Annu Symp Proc - Mapping annotations with textual evidence using an scLDA model. ( 0,731373806303411 )
Int J Med Inform - Detecting temporal expressions in medical narratives. ( 0,726142809238907 )
J Biomed Inform - Lessons learnt from the DDIExtraction-2013 Shared Task. ( 0,724291420537639 )
AMIA Annu Symp Proc - Towards a semantic lexicon for clinical natural language processing. ( 0,724018338139223 )
J. Med. Internet Res. - Natural supplements for H1N1 influenza: retrospective observational infodemiology study of information and search activity on the Internet. ( 0,723935997179636 )
Comput Math Methods Med - Ranking biomedical annotations with annotator's semantic relevancy. ( 0,721498148012752 )
J Am Med Inform Assoc - 2010 i2b2/VA challenge on concepts, assertions, and relations in clinical text. ( 0,719668010130443 )
J Am Med Inform Assoc - MITRE system for clinical assertion status classification. ( 0,717693922504532 )
Int J Med Inform - Detection of infectious symptoms from VA emergency department and primary care clinical documentation. ( 0,716578322856202 )
AMIA Annu Symp Proc - A cloud-based approach to medical NLP. ( 0,713413707682818 )
J Biomed Inform - A new clustering method for detecting rare senses of abbreviations in clinical notes. ( 0,711988506571621 )
Comput. Biol. Med. - A P300-based brain computer interface system for words typing. ( 0,711108770016133 )
Int J Med Inform - Bootstrapping a de-identification system for narrative patient records: cost-performance tradeoffs. ( 0,710511429900364 )
J Biomed Inform - Text de-identification for privacy protection: a study of its impact on clinical text information content. ( 0,709883702578905 )
J Biomed Inform - Semantator: semantic annotator for converting biomedical text to linked data. ( 0,709448774200662 )
AMIA Annu Symp Proc - Automatically pairing measured findings across narrative abdomen CT reports. ( 0,708811911147893 )
J Biomed Inform - Identifying non-elliptical entity mentions in a coordinated NP with ellipses. ( 0,707788591255697 )
AMIA Annu Symp Proc - Developing a section labeler for clinical documents. ( 0,707546622880054 )
J Biomed Inform - Evaluating measures of semantic similarity and relatedness to disambiguate terms in biomedical text. ( 0,706333884944172 )
AMIA Annu Symp Proc - Natural language processing to extract follow-up provider information from hospital discharge summaries. ( 0,705460160529596 )
AMIA Annu Symp Proc - Extracting semantic lexicons from discharge summaries using machine learning and the C-Value method. ( 0,703973791281079 )
Brief. Bioinformatics - A survey on annotation tools for the biomedical literature. ( 0,703444378528413 )
AMIA Annu Symp Proc - Voice-dictated versus typed-in clinician notes: linguistic properties and the potential implications on natural language processing. ( 0,697548559967741 )
J Biomed Inform - Enhancing clinical concept extraction with distributional semantics. ( 0,695972008292867 )
J Biomed Inform - Automatically extracting information needs from complex clinical questions. ( 0,693625552918921 )
J Am Med Inform Assoc - Large-scale evaluation of automated clinical note de-identification and its impact on information extraction. ( 0,691323388082321 )
J Am Med Inform Assoc - Automated clinical trial eligibility prescreening: increasing the efficiency of patient identification for clinical trials in the emergency department. ( 0,689221583238633 )
J Am Med Inform Assoc - Using rule-based natural language processing to improve disease normalization in biomedical text. ( 0,687913890586185 )
J Biomed Inform - Common data model for natural language processing based on two existing standard information models: CDA+GrAF. ( 0,687260610691521 )
J Am Med Inform Assoc - Drug side effect extraction from clinical narratives of psychiatry and psychology patients. ( 0,68629166622891 )
J Am Med Inform Assoc - Comparison of a semi-automatic annotation tool and a natural language processing application for the generation of clinical statement entries. ( 0,686272126789003 )
J Biomed Inform - Ontology modularization to improve semantic medical image annotation. ( 0,683969600734086 )
J Biomed Inform - Using text to build semantic networks for pharmacogenomics. ( 0,683408492497656 )
AMIA Annu Symp Proc - It's about this and that: a description of anaphoric expressions in clinical text. ( 0,680328871550067 )
J Biomed Inform - Relation mining experiments in the pharmacogenomics domain. ( 0,679803127578422 )
J. Med. Internet Res. - Evaluating a web-based clinical decision support system for language disorders screening in a nursery school. ( 0,678921841802274 )
BMC Med Inform Decis Mak - The freetext matching algorithm: a computer program to extract diagnoses and causes of death from unstructured text in electronic health records. ( 0,678287381689971 )
J Am Med Inform Assoc - Toward creation of a cancer drug toxicity knowledge base: automatically extracting cancer drug-side effect relationships from the literature. ( 0,67809675123607 )
J Biomed Inform - Text summarization in the biomedical domain: a systematic review of recent research. ( 0,67773625950564 )
J Biomed Inform - PREDOSE: a semantic web platform for drug abuse epidemiology using social media. ( 0,676391106563888 )
J Biomed Inform - Degree centrality for semantic abstraction summarization of therapeutic studies. ( 0,6750885432523 )
J Am Med Inform Assoc - A study of machine-learning-based approaches to extract clinical entities and their assertions from discharge summaries. ( 0,674442995678988 )
J Biomed Inform - The DDI corpus: an annotated corpus with pharmacological substances and drug-drug interactions. ( 0,673867301309814 )