Int J Comput Assist Radiol Surg - A neonatal brain MR image template of 1 week newborn.

Tópicos

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Resumo

RPOSE: Magnetic resonance imaging (MRI) is often used to detect and treat neonatal cerebral disorders. However, neonatal MR image interpretation is limited by intra- and inter-observer variability. To reduce such variability, a template-based computer-aided diagnosis system is being developed, and several methods for creating templates were evaluated.METHOD: Spatial normalization for each individual's MR images is used to accommodate the individual variation in brain shape. Because the conventional normalization uses as adult brain template, it can be difficult to analyze the neonatal brain, as there are large difference between the adult brain and the neonatal brain. This article investigates three approaches for defining a neonatal template for 1-week-old newborns for diagnosing neonatal cerebral disorders. The first approach uses an individual neonatal head as the template. The second approach applies skull stripping to the first approach, and the third approach produces a template by averaging brain MR images of 7 neonates. To validate the approaches, the normalization accuracy was evaluated using mutual information and anatomical landmarks.RESULTS: The experimental results of 7 neonates (revised age 5.6 ? 17.6 days) showed that normalization accuracy was significantly higher with the third approach than with the conventional adult template and the other two approaches (P <?0.01).CONCLUSION: Three approaches to neonatal brain template matching for spinal normalization of MRI scans were applied, demonstrating that a population average gave the best results.

Resumo Limpo

rpose magnet reson imag mri often use detect treat neonat cerebr disord howev neonat mr imag interpret limit intra interobserv variabl reduc variabl templatebas computeraid diagnosi system develop sever method creat templat evaluatedmethod spatial normal individu mr imag use accommod individu variat brain shape convent normal use adult brain templat can difficult analyz neonat brain larg differ adult brain neonat brain articl investig three approach defin neonat templat weekold newborn diagnos neonat cerebr disord first approach use individu neonat head templat second approach appli skull strip first approach third approach produc templat averag brain mr imag neonat valid approach normal accuraci evalu use mutual inform anatom landmarksresult experiment result neonat revis age day show normal accuraci signific higher third approach convent adult templat two approach p conclus three approach neonat brain templat match spinal normal mri scan appli demonstr popul averag gave best result

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