Int J Comput Assist Radiol Surg - Independent prognostic value of whole-body metabolic tumor burden from FDG-PET in non-small cell lung cancer.

Tópicos

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Resumo

RPOSE: To determine whether whole-body metabolic tumor burden, measured as either metabolic tumor volume (MTVWB) or total lesion glycolysis (TLGWB), using FDG-PET/CT is an independent prognostic marker in non-small cell lung cancer (NSCLC).METHODS: 328 patients with histologically proven NSCLC were identified for this retrospective analysis. This study was approved by our Institutional Review Board. All patients underwent baseline (18)F-FDG-PET/CT scan imaging before therapy. The MTVWB, TLGWB, maximum standardized uptake value (SUVmaxWB) and mean standardized uptake value (SUVmeanWB) of tumors throughout the whole body were measured from FDG-PET images with semi-automated 3D contouring software.RESULTS: In univariate analysis, there was a statistically significant association of overall survival (OS) with the MTVWB (hazard ratio (HR) = 1.62, p?<?0.001), TLGWB (HR = 1.47, p?<?0.001). The patients with a MTVWB?= median of 65.7?ml and TLGWB?= median of 205.11 SUVmean * ml had a median OS of 41.1 and 35.4?months compared with 9.5 and 9.7?months for those with a MTVWB >?65.7?ml and TLGWB?>?205.11?SUVmean * ml, respectively. From a series of multivariate Cox regression models, the MTVWB and TLGWB were significantly better than SUVmaxWB and SUVmeanWB at prognostication and significantly associated with patients' OS with HRs of 1.50 (p?<?0.001) and 1.42 (p?<?0.001), respectively, after adjustment for patient's age, gender and treatment intent as well as the tumor SUVmaxWB, histology and stage.CONCLUSIONS: MTVWB and TLGWB as metabolic tumor burden measurements in (18)F-FDG-PET/CT are independent prognostic markers and are significantly better than SUVmaxWB and SUVmeanWB at prognostication.

Resumo Limpo

rpose determin whether wholebodi metabol tumor burden measur either metabol tumor volum mtvwb total lesion glycolysi tlgwb use fdgpetct independ prognost marker nonsmal cell lung cancer nsclcmethod patient histolog proven nsclc identifi retrospect analysi studi approv institut review board patient underw baselin ffdgpetct scan imag therapi mtvwb tlgwb maximum standard uptak valu suvmaxwb mean standard uptak valu suvmeanwb tumor throughout whole bodi measur fdgpet imag semiautom d contour softwareresult univari analysi statist signific associ overal surviv os mtvwb hazard ratio hr p tlgwb hr p patient mtvwb median ml tlgwb median suvmean ml median os month compar month mtvwb ml tlgwbsuvmean ml respect seri multivari cox regress model mtvwb tlgwb signific better suvmaxwb suvmeanwb prognost signific associ patient os hrs p p respect adjust patient age gender treatment intent well tumor suvmaxwb histolog stageconclus mtvwb tlgwb metabol tumor burden measur ffdgpetct independ prognost marker signific better suvmaxwb suvmeanwb prognost

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