Int J Comput Assist Radiol Surg - fMRI assessment of upper extremity related brain activation with an MRI-compatible manipulandum.


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RPOSE: Longitudinal studies to evaluate the effect of rehabilitative therapies require an objective, reproducible and quantitative means for testing function in vivo. An fMRI assessment tool for upper extremity related brain activation using an MRI-compatible manipulandum was developed and tested for use in neurorehabilitation research.METHODS: Fifteen healthy, right-handed subjects participated in two fMRI sessions, which were three to four weeks apart. A block design paradigm, composed of three conditions of subject-passive movement, subject-active movement and rest, was employed for the fMRI recordings. During the rest condition, subjects simply held the device handle without applying any force or movement. The same type of auditory and visual instructions were given in all the three conditions, guiding the subjects to perform the motor tasks interactively with the MRI-compatible arm manipulandum. The tasks were controlled across the fMRI sessions. The subjects' brain activation was recorded by fMRI, and their behavioral performance was recorded by the manipulandum. The brain network activated by the subjects' interaction with the manipulandum was identified, and the reproducibility and reliability of the obtained activation were determined.RESULTS: All subjects completed the trial protocol. Two subjects were excluded from analysis due to head motion artifacts. All passive movements were performed well. Four out of the total 780 active movements were missed by two subjects. Brain activation was found in the contralateral sensorimotor cortex, secondary somatosensory cortex and non-primary motor cortex as well as in subcortical areas in the thalamus, basal ganglia and the cerebellum. These activations were consistent across the two fMRI sessions.CONCLUSION: The MRI-compatible manipulandum elicited robust and reproducible brain activations in healthy subjects during the subject-active and subject-passive upper extremity motor tasks with a block design paradigm. This system is promising for many applications in neurorehabilitation research and may be useful for longitudinal studies.

Resumo Limpo

rpose longitudin studi evalu effect rehabilit therapi requir object reproduc quantit mean test function vivo fmri assess tool upper extrem relat brain activ use mricompat manipulandum develop test use neurorehabilit researchmethod fifteen healthi righthand subject particip two fmri session three four week apart block design paradigm compos three condit subjectpass movement subjectact movement rest employ fmri record rest condit subject simpli held devic handl without appli forc movement type auditori visual instruct given three condit guid subject perform motor task interact mricompat arm manipulandum task control across fmri session subject brain activ record fmri behavior perform record manipulandum brain network activ subject interact manipulandum identifi reproduc reliabl obtain activ determinedresult subject complet trial protocol two subject exclud analysi due head motion artifact passiv movement perform well four total activ movement miss two subject brain activ found contralater sensorimotor cortex secondari somatosensori cortex nonprimari motor cortex well subcort area thalamus basal ganglia cerebellum activ consist across two fmri sessionsconclus mricompat manipulandum elicit robust reproduc brain activ healthi subject subjectact subjectpass upper extrem motor task block design paradigm system promis mani applic neurorehabilit research may use longitudin studi

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