Int J Comput Assist Radiol Surg - Expert-driven label fusion in multi-atlas-based segmentation of the prostate using weighted atlases.

Tópicos

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Resumo

RPOSE: Automated segmentation is required for radiotherapy treatment planning, and multi-atlas methods are frequently used for this purpose. The combination of multiple intermediate results from multi-atlas segmentation into a single segmentation map can be achieved by label fusion. A method that includes expert knowledge in the label fusion phase of multi-atlas-based segmentation was developed. The method was tested by application to prostate segmentation, and the accuracy was compared to standard techniques.METHODS: The selective and iterative method for performance level estimation (SIMPLE) algorithm for label fusion was modified with a weight map given by an expert that indicates the importance of each region in the evaluation of segmentation results. Voxel-based weights specified by an expert when performing the label fusion step in atlas-based segmentation were introduced into the modified SIMPLE algorithm. These weights incorporate expert knowledge on accuracy requirements in different regions of a segmentation. Using this knowledge, segmentation accuracy in regions known to be important can be improved by sacrificing segmentation accuracy in less important regions. Contextual information such as the presence of vulnerable tissue is then used in the segmentation process. This method using weight maps to fine-tune the result of multi-atlas-based segmentation was tested using a set of 146 atlas images consisting of an MR image of the lower abdomen and a prostate segmentation. Each image served as a target in a set of leave-one-out experiments. These experiments were repeated for a weight map derived from the clinical practice in our hospital.RESULTS: The segmentation accuracy increased 6?% in regions that border vulnerable tissue using expert-specified voxel-based weight maps. This was achieved at the cost of a 4?% decrease in accuracy in less clinically relevant regions.CONCLUSION: The inclusion of expert knowledge in a multi-atlas-based segmentation procedure was shown to be feasible for prostate segmentation. This method allows an expert to ensure that automatic segmentation is most accurate in critical regions. This improved local accuracy can increase the practical value of automatic segmentation.

Resumo Limpo

rpose autom segment requir radiotherapi treatment plan multiatla method frequent use purpos combin multipl intermedi result multiatla segment singl segment map can achiev label fusion method includ expert knowledg label fusion phase multiatlasbas segment develop method test applic prostat segment accuraci compar standard techniquesmethod select iter method perform level estim simpl algorithm label fusion modifi weight map given expert indic import region evalu segment result voxelbas weight specifi expert perform label fusion step atlasbas segment introduc modifi simpl algorithm weight incorpor expert knowledg accuraci requir differ region segment use knowledg segment accuraci region known import can improv sacrif segment accuraci less import region contextu inform presenc vulner tissu use segment process method use weight map finetun result multiatlasbas segment test use set atlas imag consist mr imag lower abdomen prostat segment imag serv target set leaveoneout experi experi repeat weight map deriv clinic practic hospitalresult segment accuraci increas region border vulner tissu use expertspecifi voxelbas weight map achiev cost decreas accuraci less clinic relev regionsconclus inclus expert knowledg multiatlasbas segment procedur shown feasibl prostat segment method allow expert ensur automat segment accur critic region improv local accuraci can increas practic valu automat segment

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