Int J Comput Assist Radiol Surg - 2D/3D image fusion of X-ray mammograms with breast MRI: visualizing dynamic contrast enhancement in mammograms.

Tópicos

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Resumo

RPOSE: Breast cancer is the most common cancer among women. The established screening method to detect breast cancer is X-ray mammography. Additionally, MRI is used for diagnosis in clinical routine. Due to complementary diagnostic information, both modalities are often read in combination. Yet, the correlation is challenging due to different dimensionality of images and different patient positioning. In this paper, we describe a method to fuse X-ray mammograms with DCE-MRI. The present study was conducted to evaluate the feasibility of the approach.METHODS: For the combination of information from both modalities, the images have to be registered using a compression simulation based on a patient-specific biomechanical model. The registered images can be compared directly. The contrast enhancement in the DCE-MRI volume is evaluated using parametric enhancement maps. A projection image of the contrast enhancement is created. The image fusion combines it with X-ray mammograms for intuitive multimodal diagnosis.RESULTS: The image fusion was evaluated using 11 clinical datasets. For 10 of 11 datasets, a good accuracy of the image registration was achieved. The overlap of contrast-enhanced regions with marked lesions in the mammogram is 61%. Lesions are clearly differentiable from surrounding tissue by the DCE-MRI projection in 10 of 11 cases.CONCLUSION: The described preliminary results are promising, thus we expect the visualization of quantitative information from dynamic MRI together with mammograms to be beneficial for multimodal diagnosis. Because of the use of clinical standard modalities, no additional image acquisition is needed.

Resumo Limpo

rpose breast cancer common cancer among women establish screen method detect breast cancer xray mammographi addit mri use diagnosi clinic routin due complementari diagnost inform modal often read combin yet correl challeng due differ dimension imag differ patient posit paper describ method fuse xray mammogram dcemri present studi conduct evalu feasibl approachmethod combin inform modal imag regist use compress simul base patientspecif biomechan model regist imag can compar direct contrast enhanc dcemri volum evalu use parametr enhanc map project imag contrast enhanc creat imag fusion combin xray mammogram intuit multimod diagnosisresult imag fusion evalu use clinic dataset dataset good accuraci imag registr achiev overlap contrastenhanc region mark lesion mammogram lesion clear differenti surround tissu dcemri project casesconclus describ preliminari result promis thus expect visual quantit inform dynam mri togeth mammogram benefici multimod diagnosi use clinic standard modal addit imag acquisit need

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