Int J Comput Assist Radiol Surg - Intelligent ePR system for evidence-based research in radiotherapy: proton therapy for prostate cancer.


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RPOSE: Proton therapy (PT) utilizes high energy particle proton beam to kill cancer cells at the target region for target cancer therapy. Due to the physical properties of the proton beam, PT delivers dose with higher precision and no exit dose compared to conventional radiotherapy. In PT, patient data are distributed among multiple systems, a hindrance to research on efficacy and effectiveness. A data mining method and a treatment plan navigator utilizing the infrastructure and data repository of a PT electronic patient record (ePR) was developed to minimize radiation toxicity and improve outcomes in prostate cancer treatment. MATERIALS/METHOD(S): The workflow of a proton therapy treatment in a radiation oncology department was reviewed, and a clinical data model and data flow were designed. A prototype PT ePR system with DICOM compliance was developed to manage prostate cancer patient images, treatment plans, and related clinical data. The ePR system consists of four main components: (1) Data Gateway; (2) ePR Server; (3) Decision Support Tools; and (4) Visualization and Display Tools. Decision support and visualization tools are currently developed based on DICOM images, DICOM-RT and DICOM-RT-ION objects data from prostate cancer patients treated with hypofractionation protocol proton therapy were used for evaluating ePR system effectiveness. Each patient data set includes a set of computed tomography (CT) DICOM images and four DICOM-RT and RT-ION objects. In addition, clinical outcomes data collected from PT cases were included to establish a knowledge base for outcomes analysis.RESULTS: A data mining search engine and an intelligent treatment plan navigator (ITPN) were developed and integrated with the ePR system. Evaluation was based on a data set of 39 PT patients and a hypothetical patient.CONCLUSIONS: The ePR system was able to facilitate the proton therapy workflow. The PT ePR system was feasible for prostate cancer patient treated with hypofractionation protocol in proton therapy. This ePR system improves efficiency in data collection and integration to facilitate outcomes analysis.

Resumo Limpo

rpose proton therapi pt util high energi particl proton beam kill cancer cell target region target cancer therapi due physic properti proton beam pt deliv dose higher precis exit dose compar convent radiotherapi pt patient data distribut among multipl system hindranc research efficaci effect data mine method treatment plan navig util infrastructur data repositori pt electron patient record epr develop minim radiat toxic improv outcom prostat cancer treatment materialsmethod workflow proton therapi treatment radiat oncolog depart review clinic data model data flow design prototyp pt epr system dicom complianc develop manag prostat cancer patient imag treatment plan relat clinic data epr system consist four main compon data gateway epr server decis support tool visual display tool decis support visual tool current develop base dicom imag dicomrt dicomrt object data prostat cancer patient treat hypofraction protocol proton therapi use evalu epr system effect patient data set includ set comput tomographi ct dicom imag four dicomrt rtion object addit clinic outcom data collect pt case includ establish knowledg base outcom analysisresult data mine search engin intellig treatment plan navig itpn develop integr epr system evalu base data set pt patient hypothet patientconclus epr system abl facilit proton therapi workflow pt epr system feasibl prostat cancer patient treat hypofraction protocol proton therapi epr system improv effici data collect integr facilit outcom analysi

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