Int J Health Geogr - Estrogen receptor positive breast cancers and their association with environmental factors.


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CKGROUND: Epidemiological studies to assess risk factors for breast cancer often do not differentiate between different types of breast cancers. We applied a general linear model to determine whether data from the Surveillance, Epidemiology, and End Results Program on annual county level age-adjusted incidence rates of breast cancer with and without estrogen receptors (ER+ and ER-) were associated with environmental pollutants.RESULTS: Our final model explained approximately 38% of the variation in the rate of ER+ breast cancer. In contrast, we were only able to explain 14% of the variation in the rate of ER- breast cancer with the same set of environmental variables. Only ER+ breast cancers were positively associated with the EPA's estimated risk of cancer based on toxic air emissions and the proportion of agricultural land in a county. Meteorological variables, including short wave radiation, temperature, precipitation, and water vapor pressure, were also significantly associated with the rate of ER+ breast cancer, after controlling for age, race, premature mortality from heart disease, and unemployment rate.CONCLUSIONS: Our findings were consistent with what we expected, given the fact that many of the commonly used pesticides and air pollutants included in the EPA cancer risk score are classified as endocrine disruptors and ER+ breast cancers respond more strongly to estrogen than ER- breast cancers. The findings of this study suggest that ER+ and ER- breast cancers have different risk factors, which should be taken into consideration in future studies that seek to understand environmental risk factors for breast cancer.

Resumo Limpo

ckground epidemiolog studi assess risk factor breast cancer often differenti differ type breast cancer appli general linear model determin whether data surveil epidemiolog end result program annual counti level ageadjust incid rate breast cancer without estrogen receptor er er associ environment pollutantsresult final model explain approxim variat rate er breast cancer contrast abl explain variat rate er breast cancer set environment variabl er breast cancer posit associ epa estim risk cancer base toxic air emiss proport agricultur land counti meteorolog variabl includ short wave radiat temperatur precipit water vapor pressur also signific associ rate er breast cancer control age race prematur mortal heart diseas unemploy rateconclus find consist expect given fact mani common use pesticid air pollut includ epa cancer risk score classifi endocrin disruptor er breast cancer respond strong estrogen er breast cancer find studi suggest er er breast cancer differ risk factor taken consider futur studi seek understand environment risk factor breast cancer

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