AMIA Annu Symp Proc - Clinical decision support for whole genome sequence information leveraging a service-oriented architecture: a prototype.

Tópicos

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Resumo

Whole genome sequence (WGS) information could soon be routinely available to clinicians to support the personalized care of their patients. At such time, clinical decision support (CDS) integrated into the clinical workflow will likely be necessary to support genome-guided clinical care. Nevertheless, developing CDS capabilities for WGS information presents many unique challenges that need to be overcome for such approaches to be effective. In this manuscript, we describe the development of a prototype CDS system that is capable of providing genome-guided CDS at the point of care and within the clinical workflow. To demonstrate the functionality of this prototype, we implemented a clinical scenario of a hypothetical patient at high risk for Lynch Syndrome based on his genomic information. We demonstrate that this system can effectively use service-oriented architecture principles and standards-based components to deliver point of care CDS for WGS information in real-time.

Resumo Limpo

whole genom sequenc wgs inform soon routin avail clinician support person care patient time clinic decis support cds integr clinic workflow will like necessari support genomeguid clinic care nevertheless develop cds capabl wgs inform present mani uniqu challeng need overcom approach effect manuscript describ develop prototyp cds system capabl provid genomeguid cds point care within clinic workflow demonstr function prototyp implement clinic scenario hypothet patient high risk lynch syndrom base genom inform demonstr system can effect use serviceori architectur principl standardsbas compon deliv point care cds wgs inform realtim

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