Int J Neural Syst - A decade of experience with deep brain stimulation for patients with refractory medial temporal lobe epilepsy.

Tópicos

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Resumo

In this study, we present long-term results from patients with medial temporal lobe (MTL) epilepsy treated with deep brain stimulation (DBS). Since 2001, 11 patients (8M) with refractory MTL epilepsy underwent MTL DBS. When unilateral DBS failed to decrease seizures by > 90%, a switch to bilateral MTL DBS was proposed. After a mean follow-up of 8.5 years (range: 67-120 months), 6/11 patients had a = 90% seizure frequency reduction with 3/6 seizure-free for > 3 years; three patients had a 40%-70% reduction and two had a < 30% reduction. In 3/5 patients switching to bilateral DBS further improved outcome. Uni- or bilateral MTL DBS did not affect neuropsychological functioning. This open study with an extended long-term follow-up demonstrates maintained efficacy of DBS for MTL epilepsy. In more than half of the patients, a seizure frequency reduction of at least 90% was reached. Bilateral MTL DBS may herald superior efficacy in unilateral MTL epilepsy.

Resumo Limpo

studi present longterm result patient medial tempor lobe mtl epilepsi treat deep brain stimul dbs sinc patient m refractori mtl epilepsi underw mtl dbs unilater dbs fail decreas seizur switch bilater mtl dbs propos mean followup year rang month patient seizur frequenc reduct seizurefre year three patient reduct two reduct patient switch bilater dbs improv outcom uni bilater mtl dbs affect neuropsycholog function open studi extend longterm followup demonstr maintain efficaci dbs mtl epilepsi half patient seizur frequenc reduct least reach bilater mtl dbs may herald superior efficaci unilater mtl epilepsi

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