Int J Neural Syst - Double-layered models can explain macro and micro structure of human sleep.

Tópicos

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{ detect(2391) sensit(1101) algorithm(908) }

Resumo

The model simulates the activity of three neural populations using a Lotka-Volterra predator-prey system and, based on neuro-anatomical and neuro-physiological recent findings, assumes that a functional thalamo-cortical gate should be crossed by 'queuing' thalamic signals and that a sleep promoting substance acts as a modulator. The resultant activity accounts for the sleep stage transitions. In accordance with sleep cycles timing, the model proves to be able to reproduce the clustering and randomness of those peculiar transient synchronized EEG patterns (TSEP) described in normal human sleep and supposed to be related to the dynamic building up of NREM sleep until its stabilization against perturbations.

Resumo Limpo

model simul activ three neural popul use lotkavolterra predatorprey system base neuroanatom neurophysiolog recent find assum function thalamocort gate cross queu thalam signal sleep promot substanc act modul result activ account sleep stage transit accord sleep cycl time model prove abl reproduc cluster random peculiar transient synchron eeg pattern tsep describ normal human sleep suppos relat dynam build nrem sleep stabil perturb

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