Int J Neural Syst - Efficacy of a new charge-balanced biphasic electrical stimulus in the isolated sciatic nerve and the hippocampal slice.

Tópicos

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Resumo

Most deep brain stimulators apply rectangular monophasic voltage pulses. By modifying the stimulus shape, it is possible to optimize stimulus efficacy and find the best compromise between clinical effect, minimal side effects and power consumption of the stimulus generator. In this study, we compared the efficacy of three types of charge-balanced biphasic pulses (CBBPs, nominal duration 100 ?s) in isolated sciatic nerves and in in vitro hippocampal brain slices of the rat. Using these two models, we tested the efficacy of several stimulus shapes exclusively on axons (in the sciatic nerve) and compared the effect with that of stimuli in the more complex neuronal network of the hippocampal slice by considering the stimulus-response relation. We showed that (i) adding an interphase gap (IPG, range 100-500 ?s) to the CBBP enhances stimulus efficacy in the rat sciatic nerve and (ii) that this type of stimuli (CBBP with IPG) is also more effective in hippocampal slices. This benefit was similar for both models of voltage and current stimulation. In our two models, asymmetric CBBPs were less beneficial. Therefore, CBBPs with IPG appear to be well suited for application to DBS, since they enhance efficacy, extend battery life and potentially reduce harmful side effects.

Resumo Limpo

deep brain stimul appli rectangular monophas voltag puls modifi stimulus shape possibl optim stimulus efficaci find best compromis clinic effect minim side effect power consumpt stimulus generat studi compar efficaci three type chargebalanc biphas puls cbbps nomin durat s isol sciatic nerv vitro hippocamp brain slice rat use two model test efficaci sever stimulus shape exclus axon sciatic nerv compar effect stimuli complex neuron network hippocamp slice consid stimulusrespons relat show ad interphas gap ipg rang s cbbp enhanc stimulus efficaci rat sciatic nerv ii type stimuli cbbp ipg also effect hippocamp slice benefit similar model voltag current stimul two model asymmetr cbbps less benefici therefor cbbps ipg appear well suit applic dbs sinc enhanc efficaci extend batteri life potenti reduc harm side effect

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