J Am Med Inform Assoc - Ability of pharmacy clinical decision-support software to alert users about clinically important drug-drug interactions.

Tópicos

{ measur(2081) correl(1212) valu(896) }
{ drug(1928) target(777) effect(648) }
{ treatment(1704) effect(941) patient(846) }
{ detect(2391) sensit(1101) algorithm(908) }
{ record(1888) medic(1808) patient(1693) }
{ design(1359) user(1324) use(1319) }
{ import(1318) role(1303) understand(862) }
{ medic(1828) order(1363) alert(1069) }
{ model(2341) predict(2261) use(1141) }
{ blood(1257) pressur(1144) flow(957) }
{ method(1969) cluster(1462) data(1082) }
{ data(3963) clinic(1234) research(1004) }
{ studi(1410) differ(1259) use(1210) }
{ method(984) reconstruct(947) comput(926) }
{ studi(1119) effect(1106) posit(819) }
{ analysi(2126) use(1163) compon(1037) }
{ problem(2511) optim(1539) algorithm(950) }
{ data(1714) softwar(1251) tool(1186) }
{ general(901) number(790) one(736) }
{ model(2656) set(1616) predict(1553) }
{ use(2086) technolog(871) perceiv(783) }
{ can(981) present(881) function(850) }
{ health(1844) social(1437) communiti(874) }
{ method(2212) result(1239) propos(1039) }
{ featur(3375) classif(2383) classifi(1994) }
{ assess(1506) score(1403) qualiti(1306) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ method(1557) propos(1049) approach(1037) }
{ case(1353) use(1143) diagnosi(1136) }
{ system(1050) medic(1026) inform(1018) }
{ spatial(1525) area(1432) region(1030) }
{ time(1939) patient(1703) rate(768) }
{ use(976) code(926) identifi(902) }
{ result(1111) use(1088) new(759) }
{ model(3404) distribut(989) bayesian(671) }
{ can(774) often(719) complex(702) }
{ imag(1947) propos(1133) code(1026) }
{ data(1737) use(1416) pattern(1282) }
{ inform(2794) health(2639) internet(1427) }
{ system(1976) rule(880) can(841) }
{ imag(1057) registr(996) error(939) }
{ bind(1733) structur(1185) ligand(1036) }
{ sequenc(1873) structur(1644) protein(1328) }
{ method(1219) similar(1157) match(930) }
{ imag(2830) propos(1344) filter(1198) }
{ network(2748) neural(1063) input(814) }
{ imag(2675) segment(2577) method(1081) }
{ patient(2315) diseas(1263) diabet(1191) }
{ take(945) account(800) differ(722) }
{ studi(2440) review(1878) systemat(933) }
{ motion(1329) object(1292) video(1091) }
{ framework(1458) process(801) describ(734) }
{ error(1145) method(1030) estim(1020) }
{ chang(1828) time(1643) increas(1301) }
{ learn(2355) train(1041) set(1003) }
{ concept(1167) ontolog(924) domain(897) }
{ clinic(1479) use(1117) guidelin(835) }
{ algorithm(1844) comput(1787) effici(935) }
{ extract(1171) text(1153) clinic(932) }
{ control(1307) perform(991) simul(935) }
{ model(2220) cell(1177) simul(1124) }
{ care(1570) inform(1187) nurs(1089) }
{ search(2224) databas(1162) retriev(909) }
{ featur(1941) imag(1645) propos(1176) }
{ howev(809) still(633) remain(590) }
{ risk(3053) factor(974) diseas(938) }
{ perform(999) metric(946) measur(919) }
{ research(1085) discuss(1038) issu(1018) }
{ visual(1396) interact(850) tool(830) }
{ compound(1573) activ(1297) structur(1058) }
{ perform(1367) use(1326) method(1137) }
{ health(3367) inform(1360) care(1135) }
{ model(3480) simul(1196) paramet(876) }
{ monitor(1329) mobil(1314) devic(1160) }
{ ehr(2073) health(1662) electron(1139) }
{ state(1844) use(1261) util(961) }
{ research(1218) medic(880) student(794) }
{ patient(2837) hospit(1953) medic(668) }
{ data(2317) use(1299) case(1017) }
{ age(1611) year(1155) adult(843) }
{ signal(2180) analysi(812) frequenc(800) }
{ cost(1906) reduc(1198) effect(832) }
{ group(2977) signific(1463) compar(1072) }
{ sampl(1606) size(1419) use(1276) }
{ gene(2352) biolog(1181) express(1162) }
{ data(3008) multipl(1320) sourc(1022) }
{ first(2504) two(1366) second(1323) }
{ intervent(3218) particip(2042) group(1664) }
{ activ(1138) subject(705) human(624) }
{ patient(1821) servic(1111) care(1106) }
{ structur(1116) can(940) graph(676) }
{ high(1669) rate(1365) level(1280) }
{ cancer(2502) breast(956) screen(824) }
{ use(1733) differ(960) four(931) }
{ implement(1333) system(1263) develop(1122) }
{ survey(1388) particip(1329) question(1065) }
{ estim(2440) model(1874) function(577) }
{ decis(3086) make(1611) patient(1517) }
{ process(1125) use(805) approach(778) }
{ activ(1452) weight(1219) physic(1104) }

Resumo

JECTIVE: Pharmacy clinical decision-support (CDS) software that contains drug-drug interaction (DDI) information may augment pharmacists' ability to detect clinically significant interactions. However, studies indicate these systems may miss some important interactions. The purpose of this study was to assess the performance of pharmacy CDS programs to detect clinically important DDIs.DESIGN: Researchers made on-site visits to 64 participating Arizona pharmacies between December 2008 and November 2009 to analyze the ability of pharmacy information systems and associated CDS to detect DDIs. Software evaluation was conducted to determine whether DDI alerts arose from prescription orders entered into the pharmacy computer systems for a standardized fictitious patient. The fictitious patient's orders consisted of 18 different medications including 19 drug pairs-13 of which were clinically significant DDIs, and six were non-interacting drug pairs.MEASUREMENTS: The sensitivity, specificity, positive predictive value, negative predictive value, and percentage of correct responses were measured for each of the pharmacy CDS systems.RESULTS: Only 18 (28%) of the 64 pharmacies correctly identified eligible interactions and non-interactions. The median percentage of correct DDI responses was 89% (range 47-100%) for participating pharmacies. The median sensitivity to detect well-established interactions was 0.85 (range 0.23-1.0); median specificity was 1.0 (range 0.83-1.0); median positive predictive value was 1.0 (range 0.88-1.0); and median negative predictive value was 0.75 (range 0.38-1.0).CONCLUSIONS: These study results indicate that many pharmacy clinical decision-support systems perform less than optimally with respect to identifying well-known, clinically relevant interactions. Comprehensive system improvements regarding the manner in which pharmacy information systems identify potential DDIs are warranted.

Resumo Limpo

jectiv pharmaci clinic decisionsupport cds softwar contain drugdrug interact ddi inform may augment pharmacist abil detect clinic signific interact howev studi indic system may miss import interact purpos studi assess perform pharmaci cds program detect clinic import ddisdesign research made onsit visit particip arizona pharmaci decemb novemb analyz abil pharmaci inform system associ cds detect ddis softwar evalu conduct determin whether ddi alert aros prescript order enter pharmaci comput system standard fictiti patient fictiti patient order consist differ medic includ drug pair clinic signific ddis six noninteract drug pairsmeasur sensit specif posit predict valu negat predict valu percentag correct respons measur pharmaci cds systemsresult pharmaci correct identifi elig interact noninteract median percentag correct ddi respons rang particip pharmaci median sensit detect wellestablish interact rang median specif rang median posit predict valu rang median negat predict valu rang conclus studi result indic mani pharmaci clinic decisionsupport system perform less optim respect identifi wellknown clinic relev interact comprehens system improv regard manner pharmaci inform system identifi potenti ddis warrant

Resumos Similares

J Clin Monit Comput - The evaluation of a non-invasive respiratory volume monitor in surgical patients undergoing elective surgery with general anesthesia. ( 0,627745223874935 )
J Am Med Inform Assoc - Is the quality of data in an electronic medical record sufficient for assessing the quality of primary care? ( 0,596279656567812 )
Comput. Biol. Med. - Inter- and intra-observer variability analysis of completely automated cIMT measurement software (AtheroEdge?) and its benchmarking against commercial ultrasound scanner and expert Readers. ( 0,595662427196521 )
Comput. Aided Surg. - Non-invasive quantification of lower limb mechanical alignment in flexion. ( 0,586673941351309 )
J Clin Monit Comput - Comparison of SNAP? II and BIS Vista indices during normothermic cardiopulmonary bypass under isoflurane anesthesia. ( 0,578043720012615 )
J Clin Monit Comput - Comparison of ear and chest probes in transcutaneous carbon dioxide pressure measurements during general anesthesia in adults. ( 0,576483298370762 )
Methods Inf Med - Measuring inter-observer agreement in contour delineation of medical imaging in a dummy run using Fleiss' kappa. ( 0,572008688877977 )
J Clin Monit Comput - The ability of the Vigileo-FloTrac system to measure cardiac output and track cardiac output changes during one-lung ventilation. ( 0,570642918784235 )
Comput. Biol. Med. - Development and evaluation of an algorithm for computer analysis of maternal heart rate during labor. ( 0,566864765009243 )
Comput Methods Programs Biomed - #NOME? ( 0,558816453385864 )
Comput Math Methods Med - Paraxial ocular measurements and entries in spectral and modal matrices: analogy and application. ( 0,558120825480684 )
J Clin Monit Comput - Masseter muscle oxygen saturation is associated with central venous oxygen saturation in patients with severe sepsis. ( 0,554480293099617 )
J Clin Monit Comput - The effects of low-dose ketamine on the analgesia nociception index (ANI) measured with the novel PhysioDoloris? analgesia monitor: a pilot study. ( 0,552004278796938 )
J Clin Monit Comput - Evaluation of the estimated continuous cardiac output monitoring system in adults and children undergoing kidney transplant surgery: a pilot study. ( 0,55146012419166 )
Comput Math Methods Med - Long-term prediction of emergency department revenue and visitor volume using autoregressive integrated moving average model. ( 0,550940229383097 )
J Clin Monit Comput - Validation of indirect calorimetry for measurement of energy expenditure in healthy volunteers undergoing pressure controlled non-invasive ventilation support. ( 0,550391390372445 )
Int J Comput Assist Radiol Surg - Mandible reconstruction using patient-specific pre-bent reconstruction plates: comparison of standard and transfer key methods. ( 0,548802548180636 )
J. Med. Internet Res. - Assessment of a new web-based sexual concurrency measurement tool for men who have sex with men. ( 0,548648948550611 )
Perspect Health Inf Manag - Projected impact of the ICD-10-CM/PCS conversion on longitudinal data and the Joint Commission Core Measures. ( 0,548627410535197 )
Med Biol Eng Comput - Fluctuation analysis of respiratory impedance waveform in asthmatic patients: effect of airway obstruction. ( 0,547460538332079 )
Comput. Biol. Med. - Gait variability and stability measures: minimum number of strides and within-session reliability. ( 0,547201165658864 )
J Clin Monit Comput - Non-invasive measurement of cardiac output in obese children and adolescents: comparison of electrical cardiometry and transthoracic Doppler echocardiography. ( 0,546548942336747 )
Med Biol Eng Comput - Quantitative evaluation of upper-limb motor control in robot-aided rehabilitation. ( 0,545965344410434 )
J Med Syst - Automatic quantification of spinal curvature in scoliotic radiograph using image processing. ( 0,543688156117171 )
J Clin Monit Comput - Validation of continuous and noninvasive hemoglobin monitoring by pulse CO-oximetry in Japanese surgical patients. ( 0,543060374282919 )
J Clin Monit Comput - The impact of systemic vascular resistance on the accuracy of the FloTrac/Vigileo? system in the perioperative period of cardiac surgery: a prospective observational comparison study. ( 0,539743137485084 )
J Clin Monit Comput - Capability of a neck worn device to measure sleep/wake, airway position, and differentiate benign snoring from obstructive sleep apnea. ( 0,538536567080686 )
J Clin Monit Comput - Cardiac index measurements by transcutaneous Doppler ultrasound and transthoracic echocardiography in adult and pediatric emergency patients. ( 0,537661991725754 )
Comput Methods Programs Biomed - Ultrasound IMT measurement on a multi-ethnic and multi-institutional database: our review and experience using four fully automated and one semi-automated methods. ( 0,534962477071313 )
J Clin Monit Comput - The accuracy of respiratory rate assessment by doctors in a London teaching hospital: a cross-sectional study. ( 0,532813277586638 )
Comput Biol Chem - Analysis of the NCI-60 dataset for cancer-related microRNA and mRNA using expression profiles. ( 0,529859258520095 )
J Clin Monit Comput - Peripheral tissue oximetry: comparing three commercial near-infrared spectroscopy oximeters on the forearm. ( 0,529176641796596 )
J Clin Monit Comput - Reliability of the volatile agent consumption display in the Draeger Primus? anesthesia machine. ( 0,520230438890635 )
Med Biol Eng Comput - Dynamic cerebral autoregulation: different signal processing methods without influence on results and reproducibility. ( 0,519299243223507 )
Comput. Biol. Med. - Approach for streamlining measurement of complex physiological phenotypes of upper airway collapsibility. ( 0,517263288476391 )
Brief. Bioinformatics - Random forest Gini importance favours SNPs with large minor allele frequency: impact, sources and recommendations. ( 0,516674429860456 )
Comput Methods Programs Biomed - Increased variation of the response index of nociception during noxious stimulation in patients during general anaesthesia. ( 0,508707838398169 )
Telemed J E Health - Autonomy versus automation: perceptions of nonmydriatic camera choice for teleretinal screening in an urban safety net clinic. ( 0,507179547167783 )
J. Med. Internet Res. - Posttreatment attrition and its predictors, attrition bias, and treatment efficacy of the anxiety online programs. ( 0,505208092587645 )
Med Biol Eng Comput - Application of gene expression programming and neural networks to predict adverse events of radical hysterectomy in cervical cancer patients. ( 0,504451987732708 )
Int J Health Geogr - Comparing the accuracy of two secondary food environment data sources in the UK across socio-economic and urban/rural divides. ( 0,504227841391441 )
IEEE J Biomed Health Inform - Identification of microsatellites in DNA using adaptive S-transform. ( 0,503580929344703 )
J Med Syst - The meaningful use of EMR in Chinese hospitals: a case study on curbing antibiotic abuse. ( 0,502458470234457 )
J Clin Monit Comput - Pulse oximetry saturation patterns detect repetitive reductions in airflow. ( 0,501341312372636 )
Comput. Biol. Med. - Time-series analysis in the medical domain: a study of Tacrolimus administration and influence on kidney graft function. ( 0,500770473925397 )
J Clin Monit Comput - SNAP II versus BIS VISTA monitor comparison during general anesthesia. ( 0,500088279674778 )
Med Biol Eng Comput - Short and longer term repeatability of ballistocardiography in a sitting position with EMFi sensor. ( 0,498880835056407 )
Comput Methods Programs Biomed - Computer simulation of structured treatment interruption for HIV infection. ( 0,497543696236449 )
J Clin Monit Comput - Noninvasive continuous beat-to-beat radial artery pressure via TL-200 applanation tonometry. ( 0,49462941086004 )
J Chem Inf Model - ANN multiscale model of anti-HIV drugs activity vs AIDS prevalence in the US at county level based on information indices of molecular graphs and social networks. ( 0,494549126377096 )
Comput Math Methods Med - The relationship between the 24h blood pressure variability and carotid intima-media thickness: a compared study. ( 0,494235974024887 )
J Chem Inf Model - Virtual affinity fingerprints for target fishing: a new application of Drug Profile Matching. ( 0,493432745250242 )
J Clin Monit Comput - Derivation of baseline lung impedance in chronic heart failure patients: use for monitoring pulmonary congestion and predicting admissions for decompensation. ( 0,491993221206507 )
J Clin Monit Comput - Cardiac parameters in children recovered from acute illness as measured by electrical cardiometry and comparisons to the literature. ( 0,489593040864265 )
Comput. Biol. Med. - A new algorithm and problems in automatic anterior eye chamber volume determining. ( 0,488229104290317 )
J Clin Monit Comput - The effect of desflurane versus propofol on regional cerebral oxygenation in the sitting position for shoulder arthroscopy. ( 0,486558030332719 )
Telemed J E Health - Automatic event detection in lung transplant recipients based on home monitoring of spirometry and symptoms. ( 0,486505613478594 )
Int J Med Inform - Computerized detection of adverse drug reactions in the medical intensive care unit. ( 0,485367259713064 )
Comput Math Methods Med - Exploratory bioinformatics study of lncRNAs in Alzheimer's disease mRNA sequences with application to drug development. ( 0,484818120751755 )
Comput Math Methods Med - Multicriteria optimization model for the study of the efficacy of skin antiaging therapy. ( 0,483872133273394 )
J Telemed Telecare - Telemedicine as a tool to mitigate cardiometabolic risk associated with serious mental illness. ( 0,48257719859744 )
J Clin Monit Comput - The mean prehospital machine; accurate prehospital non-invasive blood pressure measurement in the critically ill patient. ( 0,481536146121362 )
Comput. Biol. Med. - Assessing the variability in respiratory acoustic thoracic imaging (RATHI). ( 0,481133991872158 )
Comput Methods Programs Biomed - First pilot trial of the STAR-Liege protocol for tight glycemic control in critically ill patients. ( 0,478688428118869 )
J Clin Monit Comput - Cardiac index assessment using bioreactance in patients undergoing cytoreductive surgery in ovarian carcinoma. ( 0,478008365411632 )
J Clin Monit Comput - An autocalibrating algorithm for non-invasive cardiac output determination based on the analysis of an arterial pressure waveform recorded with radial artery applanation tonometry: a proof of concept pilot analysis. ( 0,477937669057266 )
J Integr Bioinform - Model reference adaptive scheme for multi-drug infusion for blood pressure control. ( 0,477703691338797 )
J Clin Monit Comput - Comparison of two different generations of NIRS devices and transducers in healthy volunteers and ICU patients. ( 0,477519953753069 )
J Telemed Telecare - Comparison of two motion sensors for use in cardiac telerehabilitation. ( 0,47738826376225 )
J Biomed Inform - LabeledIn: cataloging labeled indications for human drugs. ( 0,476395513683671 )
J Integr Bioinform - An integrated dataset for in silico drug discovery. ( 0,47497109246474 )
J Clin Monit Comput - The relative trending accuracy of noninvasive continuous hemoglobin monitoring during hemodialysis in critically ill patients. ( 0,472867889752305 )
Wiley Interdiscip Rev Syst Biol Med - Systems biology-embedded target validation: improving efficacy in drug discovery. ( 0,472605252313866 )
J Clin Monit Comput - Comprehensive diagnosis of whole-body acid-base and fluid-electrolyte disorders using a mathematical model and whole-body base excess. ( 0,472004269021129 )
Brief. Bioinformatics - A comparative study of statistical methods used to identify dependencies between gene expression signals. ( 0,471653331005987 )
Int J Comput Assist Radiol Surg - New method for internal anal sphincter measurements: feasibility study. ( 0,47013123770529 )
J Clin Monit Comput - Noninvasive cardiac output monitoring during exercise testing: Nexfin pulse contour analysis compared to an inert gas rebreathing method and respired gas analysis. ( 0,469234059170294 )
J Biomed Inform - Identifying potential adverse effects using the web: a new approach to medical hypothesis generation. ( 0,467898730035148 )
J Clin Monit Comput - Comparison of spectral entropy and BIS VISTA? monitor during general anesthesia for cardiac surgery. ( 0,467831983275292 )
Comput Methods Programs Biomed - stab: an R package for drug stability data analysis. ( 0,467533678566621 )
Comput Biol Chem - Pharmacokinetic analysis of multi PEG-theophylline conjugates. ( 0,467025464013559 )
Brief. Bioinformatics - Comparative study of computational methods to detect the correlated reaction sets in biochemical networks. ( 0,466775086236037 )
J Chem Inf Model - Adverse drug events: database construction and in silico prediction. ( 0,466416893407426 )
Appl Clin Inform - Lessons learned from developing a drug evidence base to support pharmacovigilance. ( 0,465071666451818 )
Comput Methods Programs Biomed - Wave reflection quantification based on pressure waveforms alone--methods, comparison, and clinical covariates. ( 0,463700965405287 )
J Clin Monit Comput - Respiratory parameters as a surrogate marker for duration of intubation: potential application of automated vital sign collection. ( 0,463054297219813 )
J. Med. Internet Res. - Online dietary intake estimation: reproducibility and validity of the Food4Me food frequency questionnaire against a 4-day weighed food record. ( 0,46302136827403 )
Comput Methods Programs Biomed - Segmentation of abdominal organs from CT using a multi-level, hierarchical neural network strategy. ( 0,46288836263028 )
J. Med. Internet Res. - Mining online social network data for biomedical research: a comparison of clinicians' and patients' perceptions about amyotrophic lateral sclerosis treatments. ( 0,462771419247577 )
AMIA Annu Symp Proc - Exploring the relationship between drug side-effects and therapeutic indications. ( 0,462249960789618 )
Int J Med Robot - Intraoperative measurement of femoral antetorsion using the anterior cortical angle method: a novel use for smartphones. ( 0,462027005267653 )
AMIA Annu Symp Proc - Structured vs. unstructured: factors affecting adverse drug reaction documentation in an EMR repository. ( 0,461878084431198 )
Med Decis Making - Treatment evolution and new standards of care: implications for cost-effectiveness analysis. ( 0,461115175794819 )
AMIA Annu Symp Proc - When you can't tell when it hurts: a preliminary algorithm to assess pain in patients who can't communicate. ( 0,460472834225701 )
J Med Syst - A high-speed drug interaction search system for ease of use in the clinical environment. ( 0,460083397674428 )
J Am Med Inform Assoc - A novel signal detection algorithm for identifying hidden drug-drug interactions in adverse event reports. ( 0,459911800052583 )
J. Med. Internet Res. - Telephone versus internet administration of self-report measures of social anxiety, depressive symptoms, and insomnia: psychometric evaluation of a method to reduce the impact of missing data. ( 0,457701358774879 )
J Clin Monit Comput - Monitoring the nociception level: a multi-parameter approach. ( 0,456706704997284 )
J. Med. Internet Res. - Activities on Facebook reveal the depressive state of users. ( 0,455906437980097 )
Res Synth Methods - Performance of a proportion-based approach to meta-analytic moderator estimation: results from Monte Carlo simulations. ( 0,455769301325989 )