J Am Med Inform Assoc - Life sciences domain analysis model.

Tópicos

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{ model(2656) set(1616) predict(1553) }
{ health(3367) inform(1360) care(1135) }
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{ use(1733) differ(960) four(931) }
{ system(1976) rule(880) can(841) }
{ motion(1329) object(1292) video(1091) }
{ treatment(1704) effect(941) patient(846) }
{ problem(2511) optim(1539) algorithm(950) }
{ design(1359) user(1324) use(1319) }
{ care(1570) inform(1187) nurs(1089) }
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{ framework(1458) process(801) describ(734) }
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{ featur(1941) imag(1645) propos(1176) }
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{ howev(809) still(633) remain(590) }
{ studi(1410) differ(1259) use(1210) }
{ risk(3053) factor(974) diseas(938) }
{ perform(999) metric(946) measur(919) }
{ model(2341) predict(2261) use(1141) }
{ studi(1119) effect(1106) posit(819) }
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{ model(3480) simul(1196) paramet(876) }
{ monitor(1329) mobil(1314) devic(1160) }
{ state(1844) use(1261) util(961) }
{ research(1218) medic(880) student(794) }
{ patient(2837) hospit(1953) medic(668) }
{ medic(1828) order(1363) alert(1069) }
{ signal(2180) analysi(812) frequenc(800) }
{ sampl(1606) size(1419) use(1276) }
{ data(3008) multipl(1320) sourc(1022) }
{ first(2504) two(1366) second(1323) }
{ intervent(3218) particip(2042) group(1664) }
{ activ(1138) subject(705) human(624) }
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{ use(2086) technolog(871) perceiv(783) }
{ can(981) present(881) function(850) }
{ analysi(2126) use(1163) compon(1037) }
{ structur(1116) can(940) graph(676) }
{ high(1669) rate(1365) level(1280) }
{ cancer(2502) breast(956) screen(824) }
{ drug(1928) target(777) effect(648) }
{ result(1111) use(1088) new(759) }
{ decis(3086) make(1611) patient(1517) }
{ process(1125) use(805) approach(778) }
{ activ(1452) weight(1219) physic(1104) }
{ method(1969) cluster(1462) data(1082) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

JECTIVE: Meaningful exchange of information is a fundamental challenge in collaborative biomedical research. To help address this, the authors developed the Life Sciences Domain Analysis Model (LS DAM), an information model that provides a framework for communication among domain experts and technical teams developing information systems to support biomedical research. The LS DAM is harmonized with the Biomedical Research Integrated Domain Group (BRIDG) model of protocol-driven clinical research. Together, these models can facilitate data exchange for translational research.MATERIALS AND METHODS: The content of the LS DAM was driven by analysis of life sciences and translational research scenarios and the concepts in the model are derived from existing information models, reference models and data exchange formats. The model is represented in the Unified Modeling Language and uses ISO 21090 data types.RESULTS: The LS DAM v2.2.1 is comprised of 130 classes and covers several core areas including Experiment, Molecular Biology, Molecular Databases and Specimen. Nearly half of these classes originate from the BRIDG model, emphasizing the semantic harmonization between these models. Validation of the LS DAM against independently derived information models, research scenarios and reference databases supports its general applicability to represent life sciences research.DISCUSSION: The LS DAM provides unambiguous definitions for concepts required to describe life sciences research. The processes established to achieve consensus among domain experts will be applied in future iterations and may be broadly applicable to other standardization efforts.CONCLUSIONS: The LS DAM provides common semantics for life sciences research. Through harmonization with BRIDG, it promotes interoperability in translational science.

Resumo Limpo

jectiv meaning exchang inform fundament challeng collabor biomed research help address author develop life scienc domain analysi model ls dam inform model provid framework communic among domain expert technic team develop inform system support biomed research ls dam harmon biomed research integr domain group bridg model protocoldriven clinic research togeth model can facilit data exchang translat researchmateri method content ls dam driven analysi life scienc translat research scenario concept model deriv exist inform model refer model data exchang format model repres unifi model languag use iso data typesresult ls dam v compris class cover sever core area includ experi molecular biolog molecular databas specimen near half class origin bridg model emphas semant harmon model valid ls dam independ deriv inform model research scenario refer databas support general applic repres life scienc researchdiscuss ls dam provid unambigu definit concept requir describ life scienc research process establish achiev consensus among domain expert will appli futur iter may broad applic standard effortsconclus ls dam provid common semant life scienc research harmon bridg promot interoper translat scienc

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