J Am Med Inform Assoc - Implementation of a deidentified federated data network for population-based cohort discovery.

Tópicos

{ data(1714) softwar(1251) tool(1186) }
{ research(1218) medic(880) student(794) }
{ concept(1167) ontolog(924) domain(897) }
{ compound(1573) activ(1297) structur(1058) }
{ system(1050) medic(1026) inform(1018) }
{ spatial(1525) area(1432) region(1030) }
{ record(1888) medic(1808) patient(1693) }
{ use(2086) technolog(871) perceiv(783) }
{ implement(1333) system(1263) develop(1122) }
{ bind(1733) structur(1185) ligand(1036) }
{ network(2748) neural(1063) input(814) }
{ decis(3086) make(1611) patient(1517) }
{ problem(2511) optim(1539) algorithm(950) }
{ search(2224) databas(1162) retriev(909) }
{ data(3963) clinic(1234) research(1004) }
{ research(1085) discuss(1038) issu(1018) }
{ health(3367) inform(1360) care(1135) }
{ state(1844) use(1261) util(961) }
{ method(1969) cluster(1462) data(1082) }
{ data(1737) use(1416) pattern(1282) }
{ imag(2830) propos(1344) filter(1198) }
{ patient(2315) diseas(1263) diabet(1191) }
{ take(945) account(800) differ(722) }
{ motion(1329) object(1292) video(1091) }
{ framework(1458) process(801) describ(734) }
{ error(1145) method(1030) estim(1020) }
{ extract(1171) text(1153) clinic(932) }
{ care(1570) inform(1187) nurs(1089) }
{ method(984) reconstruct(947) comput(926) }
{ import(1318) role(1303) understand(862) }
{ cost(1906) reduc(1198) effect(832) }
{ group(2977) signific(1463) compar(1072) }
{ data(3008) multipl(1320) sourc(1022) }
{ first(2504) two(1366) second(1323) }
{ intervent(3218) particip(2042) group(1664) }
{ health(1844) social(1437) communiti(874) }
{ estim(2440) model(1874) function(577) }
{ model(3404) distribut(989) bayesian(671) }
{ can(774) often(719) complex(702) }
{ imag(1947) propos(1133) code(1026) }
{ inform(2794) health(2639) internet(1427) }
{ system(1976) rule(880) can(841) }
{ measur(2081) correl(1212) valu(896) }
{ imag(1057) registr(996) error(939) }
{ sequenc(1873) structur(1644) protein(1328) }
{ method(1219) similar(1157) match(930) }
{ featur(3375) classif(2383) classifi(1994) }
{ imag(2675) segment(2577) method(1081) }
{ studi(2440) review(1878) systemat(933) }
{ assess(1506) score(1403) qualiti(1306) }
{ treatment(1704) effect(941) patient(846) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ chang(1828) time(1643) increas(1301) }
{ learn(2355) train(1041) set(1003) }
{ clinic(1479) use(1117) guidelin(835) }
{ algorithm(1844) comput(1787) effici(935) }
{ method(1557) propos(1049) approach(1037) }
{ design(1359) user(1324) use(1319) }
{ control(1307) perform(991) simul(935) }
{ model(2220) cell(1177) simul(1124) }
{ general(901) number(790) one(736) }
{ featur(1941) imag(1645) propos(1176) }
{ case(1353) use(1143) diagnosi(1136) }
{ howev(809) still(633) remain(590) }
{ studi(1410) differ(1259) use(1210) }
{ risk(3053) factor(974) diseas(938) }
{ perform(999) metric(946) measur(919) }
{ model(2341) predict(2261) use(1141) }
{ visual(1396) interact(850) tool(830) }
{ perform(1367) use(1326) method(1137) }
{ studi(1119) effect(1106) posit(819) }
{ blood(1257) pressur(1144) flow(957) }
{ model(3480) simul(1196) paramet(876) }
{ monitor(1329) mobil(1314) devic(1160) }
{ ehr(2073) health(1662) electron(1139) }
{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ data(2317) use(1299) case(1017) }
{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ signal(2180) analysi(812) frequenc(800) }
{ sampl(1606) size(1419) use(1276) }
{ gene(2352) biolog(1181) express(1162) }
{ activ(1138) subject(705) human(624) }
{ time(1939) patient(1703) rate(768) }
{ patient(1821) servic(1111) care(1106) }
{ can(981) present(881) function(850) }
{ analysi(2126) use(1163) compon(1037) }
{ structur(1116) can(940) graph(676) }
{ high(1669) rate(1365) level(1280) }
{ cancer(2502) breast(956) screen(824) }
{ use(976) code(926) identifi(902) }
{ use(1733) differ(960) four(931) }
{ drug(1928) target(777) effect(648) }
{ result(1111) use(1088) new(759) }
{ survey(1388) particip(1329) question(1065) }
{ process(1125) use(805) approach(778) }
{ activ(1452) weight(1219) physic(1104) }
{ method(2212) result(1239) propos(1039) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

JECTIVE: The Cross-Institutional Clinical Translational Research project explored a federated query tool and looked at how this tool can facilitate clinical trial cohort discovery by managing access to aggregate patient data located within unaffiliated academic medical centers.METHODS: The project adapted software from the Informatics for Integrating Biology and the Bedside (i2b2) program to connect three Clinical Translational Research Award sites: University of Washington, Seattle, University of California, Davis, and University of California, San Francisco. The project developed an iterative spiral software development model to support the implementation and coordination of this multisite data resource.RESULTS: By standardizing technical infrastructures, policies, and semantics, the project enabled federated querying of deidentified clinical datasets stored in separate institutional environments and identified barriers to engaging users for measuring utility.DISCUSSION: The authors discuss the iterative development and evaluation phases of the project and highlight the challenges identified and the lessons learned.CONCLUSION: The common system architecture and translational processes provide high-level (aggregate) deidentified access to a large patient population (>5 million patients), and represent a novel and extensible resource. Enhancing the network for more focused disease areas will require research-driven partnerships represented across all partner sites.

Resumo Limpo

jectiv crossinstitut clinic translat research project explor feder queri tool look tool can facilit clinic trial cohort discoveri manag access aggreg patient data locat within unaffili academ medic centersmethod project adapt softwar informat integr biolog bedsid ib program connect three clinic translat research award site univers washington seattl univers california davi univers california san francisco project develop iter spiral softwar develop model support implement coordin multisit data resourceresult standard technic infrastructur polici semant project enabl feder queri deidentifi clinic dataset store separ institut environ identifi barrier engag user measur utilitydiscuss author discuss iter develop evalu phase project highlight challeng identifi lesson learnedconclus common system architectur translat process provid highlevel aggreg deidentifi access larg patient popul million patient repres novel extens resourc enhanc network focus diseas area will requir researchdriven partnership repres across partner site

Resumos Similares

J Am Med Inform Assoc - Enabling collaborative research using the Biomedical Informatics Research Network (BIRN). ( 0,767215056426965 )
AMIA Annu Symp Proc - Supporting the Collaborative Authoring of ICD-11 with WebProt?g?. ( 0,766616187474723 )
Brief. Bioinformatics - A toolbox for developing bioinformatics software. ( 0,755112060731259 )
J Am Med Inform Assoc - Exposome informatics: considerations for the design of future biomedical research information systems. ( 0,750266098463045 )
AMIA Annu Symp Proc - The ontology life cycle: Integrated tools for editing, publishing, peer review, and evolution of ontologies. ( 0,727852209786567 )
Comput Methods Programs Biomed - Medical faculties educational network: multidimensional quality assessment. ( 0,722227665154221 )
Comput Methods Programs Biomed - AIBench: a rapid application development framework for translational research in biomedicine. ( 0,71329644531443 )
Wiley Interdiscip Rev Syst Biol Med - Accelerating cancer systems biology research through Semantic Web technology. ( 0,711543928034926 )
Brief. Bioinformatics - The semantic web in translational medicine: current applications and future directions. ( 0,697692014329008 )
J Biomed Inform - NanoParticle Ontology for cancer nanotechnology research. ( 0,69766432576097 )
BMC Med Inform Decis Mak - Text data extraction for a prospective, research-focused data mart: implementation and validation. ( 0,697540627999075 )
Methods Inf Med - Supporting translational research on inherited cardiomyopathies through information technology. ( 0,694468422416166 )
AMIA Annu Symp Proc - The TRITON Project: Design and Implementation of an Integrative Translational Research Information Management Platform. ( 0,694382481572572 )
Brief. Bioinformatics - Tutorial videos of bioinformatics resources: online distribution trial in Japan named TogoTV. ( 0,693498749085439 )
Methods Inf Med - Enabling GeneHunter as a grid service: a case study for implementing analytical services in biomedical grids. ( 0,688880271432412 )
Curr Protoc Bioinformatics - Using EMBL-EBI Services via Web Interface and Programmatically via Web Services. ( 0,684574576329887 )
Int J Med Inform - The Epilepsy Phenome/Genome Project (EPGP) informatics platform. ( 0,67715906357836 )
J Med Syst - Predefined three tier business intelligence architecture in healthcare enterprise. ( 0,675525830458534 )
Methods Inf Med - Missing semantic annotation in databases. The root cause for data integration and migration problems in information systems. ( 0,673050537368635 )
AMIA Annu Symp Proc - The SHARPn project on secondary use of Electronic Medical Record data: progress, plans, and possibilities. ( 0,672031139956368 )
J Am Med Inform Assoc - Leveraging the national cyberinfrastructure for biomedical research. ( 0,669938170063353 )
J Am Med Inform Assoc - The National Center for Biomedical Ontology. ( 0,668482037466847 )
Brief. Bioinformatics - Knowledge sharing and collaboration in translational research, and the DC-THERA Directory. ( 0,665728537818027 )
J Chem Inf Model - DDLm: a new dictionary definition language. ( 0,661682446681124 )
Brief. Bioinformatics - Architecture for interoperable software in biology. ( 0,661384919088883 )
J Biomed Inform - Modular design, application architecture, and usage of a self-service model for enterprise data delivery: the Duke Enterprise Data Unified Content Explorer (DEDUCE). ( 0,660219085258358 )
Health Info Libr J - Dissemination of public health information: key tools utilised by the NECOBELAC network in Europe and Latin America. ( 0,660095131510985 )
Int J Comput Assist Radiol Surg - Development and implementation of an integrated mobile situational awareness iPhone application VigiVU? at an academic medical center. ( 0,659033890769855 )
Med Biol Eng Comput - Towards a flexible middleware for context-aware pervasive and wearable systems. ( 0,657455270256987 )
Brief. Bioinformatics - Bioinformatics training: selecting an appropriate learning content management system--an example from the European Bioinformatics Institute. ( 0,65573101375964 )
Comput Methods Programs Biomed - Social Web mining and exploitation for serious applications: Technosocial Predictive Analytics and related technologies for public health, environmental and national security surveillance. ( 0,653501627461756 )
AMIA Annu Symp Proc - Information warehouse - a comprehensive informatics platform for business, clinical, and research applications. ( 0,652225336132882 )
Methods Inf Med - MedSkills: a learning environment for evidence-based medical skills. ( 0,651221493676446 )
Brief. Bioinformatics - The NGS WikiBook: a dynamic collaborative online training effort with long-term sustainability. ( 0,650473314785055 )
Appl Clin Inform - Design and multicentric implementation of a generic software architecture for patient recruitment systems re-using existing HIS tools and routine patient data. ( 0,649339251956511 )
J Chem Inf Model - ChemCalc: a building block for tomorrow's chemical infrastructure. ( 0,643980697460983 )
Brief. Bioinformatics - Buying in to bioinformatics: an introduction to commercial sequence analysis software. ( 0,643683004055162 )
Int J Health Geogr - Open-Source web-based Geographical Information System for health exposure assessment. ( 0,639168823279179 )
Int J Comput Assist Radiol Surg - A DICOM-based 2nd generation Molecular Imaging Data Grid implementing the IHE XDS-i integration profile. ( 0,636377118000457 )
J Biomed Inform - ReVeaLD: a user-driven domain-specific interactive search platform for biomedical research. ( 0,636019871227106 )
J Am Med Inform Assoc - Bionimbus: a cloud for managing, analyzing and sharing large genomics datasets. ( 0,633917976188766 )
BMC Med Inform Decis Mak - Clinical software development for the Web: lessons learned from the BOADICEA project. ( 0,633852787576877 )
J Am Med Inform Assoc - iDASH: integrating data for analysis, anonymization, and sharing. ( 0,632739652305227 )
J Chem Inf Model - JGromacs: a Java package for analyzing protein simulations. ( 0,631466913773294 )
Brief. Bioinformatics - Web scraping technologies in an API world. ( 0,630375033197751 )
J Med Syst - LAS: a software platform to support oncological data management. ( 0,628362101171642 )
J Chem Inf Model - AsteriX: a Web server to automatically extract ligand coordinates from figures in PDF articles. ( 0,62714962754681 )
J Chem Inf Model - ZINC: a free tool to discover chemistry for biology. ( 0,62707850370206 )
J Integr Bioinform - Bioinformatics strategies in life sciences: from data processing and data warehousing to biological knowledge extraction. ( 0,620552185400303 )
AMIA Annu Symp Proc - ARX--A Comprehensive Tool for Anonymizing Biomedical Data. ( 0,61931098754243 )
J Am Med Inform Assoc - Clinical research informatics: a conceptual perspective. ( 0,618662844884519 )
BMC Med Inform Decis Mak - XML-BSPM: an XML format for storing Body Surface Potential Map recordings. ( 0,617359295938302 )
J Chem Inf Model - DockoMatic 2.0: high throughput inverse virtual screening and homology modeling. ( 0,617231253252635 )
BMC Med Inform Decis Mak - e-MIR2: a public online inventory of medical informatics resources. ( 0,616069434938197 )
J Biomed Inform - Cloud-based bioinformatics workflow platform for large-scale next-generation sequencing analyses. ( 0,615123712358143 )
J Med Syst - A data types profile suitable for use with ISO EN 13606. ( 0,614443258328133 )
J Am Med Inform Assoc - AMIA Board white paper: definition of biomedical informatics and specification of core competencies for graduate education in the discipline. ( 0,61124608055891 )
Int J Comput Assist Radiol Surg - The Medical Imaging Interaction Toolkit: challenges and advances : 10 years of open-source development. ( 0,611184644757279 )
Perspect Health Inf Manag - ICD-10-CM/PCS: transferring knowledge from ICD-9-CM. ( 0,610448157306372 )
J. Med. Internet Res. - Interactive algorithms for teaching and learning acute medicine in the network of medical faculties MEFANET. ( 0,609932867653359 )
J Chem Inf Model - ThermoData Engine (TDE): software implementation of the dynamic data evaluation concept. 9. Extensible thermodynamic constraints for pure compounds and new model developments. ( 0,608465393105503 )
Comput Methods Programs Biomed - Using off-the-shelf tools for terabyte-scale waveform recording in intensive care: computer system design, database description and lessons learned. ( 0,606392766096104 )
Brief. Bioinformatics - Mathematical modeling of biological systems. ( 0,605463011492826 )
J Chem Inf Model - CYANOS: a data management system for natural product drug discovery efforts using cultured microorganisms. ( 0,603278088051014 )
J Biomed Inform - The Analytic Information Warehouse (AIW): a platform for analytics using electronic health record data. ( 0,603035516160515 )
J Am Med Inform Assoc - Direct2Experts: a pilot national network to demonstrate interoperability among research-networking platforms. ( 0,602057869314966 )
Health Info Libr J - An investigation into the move towards electronic journals: a case study of NHS libraries in Kent, Surrey and Sussex. ( 0,601457429394575 )
J Chem Inf Model - NAOMI: on the almost trivial task of reading molecules from different file formats. ( 0,600615533442035 )
Brief. Bioinformatics - Bioinformatics education dissemination with an evolutionary problem solving perspective. ( 0,599302893360863 )
J Chem Inf Model - CycloPs: generating virtual libraries of cyclized and constrained peptides including nonnatural amino acids. ( 0,599038476516812 )
Int J Med Inform - Development and evaluation of SOA-based AAL services in real-life environments: a case study and lessons learned. ( 0,598794381221773 )
Brief. Bioinformatics - OpenHelix: bioinformatics education outside of a different box. ( 0,598534962573679 )
J. Med. Internet Res. - Beyond open big data: addressing unreliable research. ( 0,598399226835546 )
Brief. Bioinformatics - Developing an online programme in computational biology. ( 0,59722801454901 )
J Med Syst - MEDWISE: an innovative public health information system infrastructure. ( 0,595429319597574 )
AMIA Annu Symp Proc - Using RxNorm and NDF-RT to classify medication data extracted from electronic health records: experiences from the Rochester Epidemiology Project. ( 0,592031662819953 )
Brief. Bioinformatics - A first course in computing with applications to biology. ( 0,589551647054224 )
J Chem Inf Model - Extensions to the STAR File syntax. ( 0,588949944108435 )
J Integr Bioinform - BacillOndex: an integrated data resource for systems and synthetic biology. ( 0,588320935695456 )
Inform Health Soc Care - arriba-lib: Analyses of user interactions with an electronic library of decision aids on the basis of log data. ( 0,588031553818438 )
Healthc (Amst) - Supporting HITECH implementation and assessing lessons for the future: The role of program evaluation. ( 0,58692668131799 )
J Med Syst - Research on application information system integration platform in medicine manufacturing enterprise. ( 0,586873060028544 )
AMIA Annu Symp Proc - Use of standard drug vocabularies in clinical research: a case study in pediatrics. ( 0,586256674484598 )
J Chem Inf Model - iBIOMES: managing and sharing biomolecular simulation data in a distributed environment. ( 0,585963472828607 )
BMC Med Inform Decis Mak - The deployment of a tissue request tracking system for the CHTN: a case study in managing change in informatics for biobanking operations. ( 0,585904731216058 )
J Am Med Inform Assoc - R engine cell: integrating R into the i2b2 software infrastructure. ( 0,58102896900245 )
J Am Med Inform Assoc - The challenges in making electronic health records accessible to patients. ( 0,578916849976983 )
Brief. Bioinformatics - Bioinformatics tools and database resources for systems genetics analysis in mice--a short review and an evaluation of future needs. ( 0,578548270147105 )
Methods Inf Med - MITK diffusion imaging. ( 0,578325869261056 )
AMIA Annu Symp Proc - Gap analysis of biomedical informatics graduate education competencies. ( 0,578234387333919 )
Telemed J E Health - An Albanian open source telemedicine platform. ( 0,577734526272416 )
IEEE J Biomed Health Inform - An interoperable system for automated diagnosis of cardiac abnormalities from electrocardiogram data. ( 0,577520348524168 )
J Chem Inf Model - Integrated project views: decision support platform for drug discovery project teams. ( 0,577185910701009 )
Int J Health Geogr - Free and simple GIS as appropriate for health mapping in a low resource setting: a case study in eastern Indonesia. ( 0,576970253693203 )
BMC Med Inform Decis Mak - Querying phenotype-genotype relationships on patient datasets using semantic web technology: the example of Cerebrotendinous xanthomatosis. ( 0,575894580813418 )
BMC Med Inform Decis Mak - People, organizational, and leadership factors impacting informatics support for clinical and translational research. ( 0,575777176849444 )
J Am Med Inform Assoc - Launching PCORnet, a national patient-centered clinical research network. ( 0,574267608891702 )
Brief. Bioinformatics - Bioinformatics Training Network (BTN): a community resource for bioinformatics trainers. ( 0,574232136297597 )
Brief. Bioinformatics - Bioinformatics opportunities for identification and study of medicinal plants. ( 0,573562071373387 )
BMC Med Inform Decis Mak - AGUIA: autonomous graphical user interface assembly for clinical trials semantic data services. ( 0,573068656984941 )