J Am Med Inform Assoc - ICD-10 codes used to identify adverse drug events in administrative data: a systematic review.

Tópicos

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Resumo

CKGROUND: Adverse drug events, the unintended and harmful effects of medications, are important outcome measures in health services research. Yet no universally accepted set of International Classification of Diseases (ICD) revision 10 codes or coding algorithms exists to ensure their consistent identification in administrative data. Our objective was to synthesize a comprehensive set of ICD-10 codes used to identify adverse drug events.METHODS: We developed a systematic search strategy and applied it to five electronic reference databases. We searched relevant medical journals, conference proceedings, electronic grey literature and bibliographies of relevant studies, and contacted content experts for unpublished studies. One author reviewed the titles and abstracts for inclusion and exclusion criteria. Two authors reviewed eligible full-text articles and abstracted data in duplicate. Data were synthesized in a qualitative manner.RESULTS: Of 4241 titles identified, 41 were included. We found a total of 827 ICD-10 codes that have been used in the medical literature to identify adverse drug events. The median number of codes used to search for adverse drug events was 190 (IQR 156-289) with a large degree of variability between studies in the numbers and types of codes used. Authors commonly used external injury (Y40.0-59.9) and disease manifestation codes. Only two papers reported on the sensitivity of their code set.CONCLUSIONS: Substantial variability exists in the methods used to identify adverse drug events in administrative data. Our work may serve as a point of reference for future research and consensus building in this area.

Resumo Limpo

ckground advers drug event unintend harm effect medic import outcom measur health servic research yet univers accept set intern classif diseas icd revis code code algorithm exist ensur consist identif administr data object synthes comprehens set icd code use identifi advers drug eventsmethod develop systemat search strategi appli five electron refer databas search relev medic journal confer proceed electron grey literatur bibliographi relev studi contact content expert unpublish studi one author review titl abstract inclus exclus criteria two author review elig fulltext articl abstract data duplic data synthes qualit mannerresult titl identifi includ found total icd code use medic literatur identifi advers drug event median number code use search advers drug event iqr larg degre variabl studi number type code use author common use extern injuri y diseas manifest code two paper report sensit code setconclus substanti variabl exist method use identifi advers drug event administr data work may serv point refer futur research consensus build area

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