J Am Med Inform Assoc - Pathology imaging informatics for quantitative analysis of whole-slide images.

Tópicos

{ research(1085) discuss(1038) issu(1018) }
{ featur(1941) imag(1645) propos(1176) }
{ extract(1171) text(1153) clinic(932) }
{ motion(1329) object(1292) video(1091) }
{ framework(1458) process(801) describ(734) }
{ clinic(1479) use(1117) guidelin(835) }
{ case(1353) use(1143) diagnosi(1136) }
{ decis(3086) make(1611) patient(1517) }
{ data(1737) use(1416) pattern(1282) }
{ sequenc(1873) structur(1644) protein(1328) }
{ search(2224) databas(1162) retriev(909) }
{ research(1218) medic(880) student(794) }
{ model(2656) set(1616) predict(1553) }
{ data(3963) clinic(1234) research(1004) }
{ first(2504) two(1366) second(1323) }
{ take(945) account(800) differ(722) }
{ treatment(1704) effect(941) patient(846) }
{ design(1359) user(1324) use(1319) }
{ care(1570) inform(1187) nurs(1089) }
{ compound(1573) activ(1297) structur(1058) }
{ record(1888) medic(1808) patient(1693) }
{ state(1844) use(1261) util(961) }
{ group(2977) signific(1463) compar(1072) }
{ cancer(2502) breast(956) screen(824) }
{ method(2212) result(1239) propos(1039) }
{ imag(2830) propos(1344) filter(1198) }
{ patient(2315) diseas(1263) diabet(1191) }
{ studi(2440) review(1878) systemat(933) }
{ learn(2355) train(1041) set(1003) }
{ data(1714) softwar(1251) tool(1186) }
{ system(1050) medic(1026) inform(1018) }
{ import(1318) role(1303) understand(862) }
{ visual(1396) interact(850) tool(830) }
{ health(3367) inform(1360) care(1135) }
{ model(3480) simul(1196) paramet(876) }
{ data(2317) use(1299) case(1017) }
{ cost(1906) reduc(1198) effect(832) }
{ model(3404) distribut(989) bayesian(671) }
{ can(774) often(719) complex(702) }
{ imag(1947) propos(1133) code(1026) }
{ inform(2794) health(2639) internet(1427) }
{ system(1976) rule(880) can(841) }
{ measur(2081) correl(1212) valu(896) }
{ imag(1057) registr(996) error(939) }
{ bind(1733) structur(1185) ligand(1036) }
{ method(1219) similar(1157) match(930) }
{ featur(3375) classif(2383) classifi(1994) }
{ network(2748) neural(1063) input(814) }
{ imag(2675) segment(2577) method(1081) }
{ assess(1506) score(1403) qualiti(1306) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ problem(2511) optim(1539) algorithm(950) }
{ error(1145) method(1030) estim(1020) }
{ chang(1828) time(1643) increas(1301) }
{ concept(1167) ontolog(924) domain(897) }
{ algorithm(1844) comput(1787) effici(935) }
{ method(1557) propos(1049) approach(1037) }
{ control(1307) perform(991) simul(935) }
{ model(2220) cell(1177) simul(1124) }
{ general(901) number(790) one(736) }
{ method(984) reconstruct(947) comput(926) }
{ howev(809) still(633) remain(590) }
{ studi(1410) differ(1259) use(1210) }
{ risk(3053) factor(974) diseas(938) }
{ perform(999) metric(946) measur(919) }
{ model(2341) predict(2261) use(1141) }
{ perform(1367) use(1326) method(1137) }
{ studi(1119) effect(1106) posit(819) }
{ blood(1257) pressur(1144) flow(957) }
{ spatial(1525) area(1432) region(1030) }
{ monitor(1329) mobil(1314) devic(1160) }
{ ehr(2073) health(1662) electron(1139) }
{ patient(2837) hospit(1953) medic(668) }
{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ signal(2180) analysi(812) frequenc(800) }
{ sampl(1606) size(1419) use(1276) }
{ gene(2352) biolog(1181) express(1162) }
{ data(3008) multipl(1320) sourc(1022) }
{ intervent(3218) particip(2042) group(1664) }
{ activ(1138) subject(705) human(624) }
{ time(1939) patient(1703) rate(768) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ can(981) present(881) function(850) }
{ analysi(2126) use(1163) compon(1037) }
{ health(1844) social(1437) communiti(874) }
{ structur(1116) can(940) graph(676) }
{ high(1669) rate(1365) level(1280) }
{ use(976) code(926) identifi(902) }
{ use(1733) differ(960) four(931) }
{ drug(1928) target(777) effect(648) }
{ result(1111) use(1088) new(759) }
{ implement(1333) system(1263) develop(1122) }
{ survey(1388) particip(1329) question(1065) }
{ estim(2440) model(1874) function(577) }
{ process(1125) use(805) approach(778) }
{ activ(1452) weight(1219) physic(1104) }
{ method(1969) cluster(1462) data(1082) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

JECTIVES: With the objective of bringing clinical decision support systems to reality, this article reviews histopathological whole-slide imaging informatics methods, associated challenges, and future research opportunities.TARGET AUDIENCE: This review targets pathologists and informaticians who have a limited understanding of the key aspects of whole-slide image (WSI) analysis and/or a limited knowledge of state-of-the-art technologies and analysis methods.SCOPE: First, we discuss the importance of imaging informatics in pathology and highlight the challenges posed by histopathological WSI. Next, we provide a thorough review of current methods for: quality control of histopathological images; feature extraction that captures image properties at the pixel, object, and semantic levels; predictive modeling that utilizes image features for diagnostic or prognostic applications; and data and information visualization that explores WSI for de novo discovery. In addition, we highlight future research directions and discuss the impact of large public repositories of histopathological data, such as the Cancer Genome Atlas, on the field of pathology informatics. Following the review, we present a case study to illustrate a clinical decision support system that begins with quality control and ends with predictive modeling for several cancer endpoints. Currently, state-of-the-art software tools only provide limited image processing capabilities instead of complete data analysis for clinical decision-making. We aim to inspire researchers to conduct more research in pathology imaging informatics so that clinical decision support can become a reality.

Resumo Limpo

jectiv object bring clinic decis support system realiti articl review histopatholog wholeslid imag informat method associ challeng futur research opportunitiestarget audienc review target pathologist informatician limit understand key aspect wholeslid imag wsi analysi andor limit knowledg stateoftheart technolog analysi methodsscop first discuss import imag informat patholog highlight challeng pose histopatholog wsi next provid thorough review current method qualiti control histopatholog imag featur extract captur imag properti pixel object semant level predict model util imag featur diagnost prognost applic data inform visual explor wsi de novo discoveri addit highlight futur research direct discuss impact larg public repositori histopatholog data cancer genom atlas field patholog informat follow review present case studi illustr clinic decis support system begin qualiti control end predict model sever cancer endpoint current stateoftheart softwar tool provid limit imag process capabl instead complet data analysi clinic decisionmak aim inspir research conduct research patholog imag informat clinic decis support can becom realiti

Resumos Similares

Int J Med Inform - Implementation science approaches for integrating eHealth research into practice and policy. ( 0,753051382767027 )
Comput Math Methods Med - Retracted: Bayes clustering and structural support vector machines for segmentation of carotid artery plaques in multicontrast MRI. ( 0,719101209402831 )
Res Synth Methods - The evolution of a new publication type: Steps and challenges of producing overviews of reviews. ( 0,717817823223994 )
J Med Syst - A review of tags anti-collision and localization protocols in RFID networks. ( 0,713127178219706 )
Brief. Bioinformatics - Environmental bio-monitoring with high-throughput sequencing. ( 0,711944405163579 )
J Biomed Inform - Natural language processing: state of the art and prospects for significant progress, a workshop sponsored by the National Library of Medicine. ( 0,710384508970138 )
Artif Intell Med - Recommendations for the ethical use and design of artificial intelligent care providers. ( 0,705612430750626 )
Curr Comput Aided Drug Des - Recent Progress on Computer-Aided Inhibitor Design of H5N1 Influenza A Virus. ( 0,693503012868428 )
J Clin Monit Comput - Endotracheal tube cuff--small important part of a big issue. ( 0,691612059314847 )
IEEE Trans Image Process - Robust radial face detection for omnidirectional vision. ( 0,678809099834758 )
Res Synth Methods - Meta-research: The art of getting it wrong. ( 0,675754470955179 )
Brief. Bioinformatics - Measuring the microbiome: perspectives on advances in DNA-based techniques for exploring microbial life. ( 0,650886074914025 )
J Biomed Inform - Cognitive informatics in biomedicine and healthcare. ( 0,639122520287444 )
Brief. Bioinformatics - Bio/chemoinformatics in India: an outlook. ( 0,637876974279683 )
J Am Med Inform Assoc - Advanced networks and computing in healthcare. ( 0,632616953654744 )
AMIA Annu Symp Proc - Probing the benefits of real-time tracking during cancer care. ( 0,628587865076161 )
Brief. Bioinformatics - The challenges of delivering bioinformatics training in the analysis of high-throughput data. ( 0,623866921846224 )
J Am Med Inform Assoc - Toward a science of learning systems: a research agenda for the high-functioning Learning Health System. ( 0,622371054806643 )
J Am Med Inform Assoc - Ethical and practical challenges to studying patients who opt out of large-scale biorepository research. ( 0,620860353876752 )
Brief. Bioinformatics - Towards more accurate prediction of protein folding rates: a review of the existing Web-based bioinformatics approaches. ( 0,620629234031031 )
Brief. Bioinformatics - Tools and collaborative environments for bioinformatics research. ( 0,615144203925315 )
J. Med. Internet Res. - Issues in mHealth: findings from key informant interviews. ( 0,607058062058518 )
Int J Med Inform - Text mining of cancer-related information: review of current status and future directions. ( 0,598665890364593 )
Comput. Biol. Med. - Computer-aided techniques for chromogenic immunohistochemistry: status and directions. ( 0,597787735492303 )
AMIA Annu Symp Proc - BioSimplify: an open source sentence simplification engine to improve recall in automatic biomedical information extraction. ( 0,593667542340195 )
J Am Med Inform Assoc - Temporal reasoning over clinical text: the state of the art. ( 0,592036627404561 )
Med Decis Making - Personalized medicine and genomics: challenges and opportunities in assessing effectiveness, cost-effectiveness, and future research priorities. ( 0,59031796434482 )
Telemed J E Health - The patient-centered medical home and health information technology. ( 0,589509505731712 )
Res Synth Methods - Methodological approaches in conducting overviews: current state in HTA agencies. ( 0,587591986363683 )
IEEE Comput Graph Appl - Automatic emotion recognition based on body movement analysis: a survey. ( 0,586588460085413 )
Brief. Bioinformatics - Protein-protein interaction and pathway databases, a graphical review. ( 0,586555875070246 )
Brief. Bioinformatics - Identifying driver mutations from sequencing data of heterogeneous tumors in the era of personalized genome sequencing. ( 0,585957574257855 )
Telemed J E Health - A standard telemental health evaluation model: the time is now. ( 0,584455336437871 )
Brief. Bioinformatics - Network inference from AP-MS data: computational challenges and solutions. ( 0,583248470442168 )
BMC Med Inform Decis Mak - Video observation in HIT development: lessons learned on benefits and challenges. ( 0,576620080935709 )
Brief. Bioinformatics - Current innovations and future challenges of network motif detection. ( 0,57144058567355 )
J Am Med Inform Assoc - An integrative framework for sensor-based measurement of teamwork in healthcare. ( 0,570960145307645 )
Wiley Interdiscip Rev Syst Biol Med - Subdiffractive microscopy: techniques, applications, and challenges. ( 0,569640883416162 )
Wiley Interdiscip Rev Syst Biol Med - Engineered tissue grafts: opportunities and challenges in regenerative medicine. ( 0,568119648122424 )
Brief. Bioinformatics - Online resources of cancer data: barriers, benefits and lessons. ( 0,567882999930043 )
Telemed J E Health - A review on telemedicine-based WBAN framework for patient monitoring. ( 0,567617510581439 )
Comput Biol Chem - Stable feature selection for biomarker discovery. ( 0,56157154680314 )
Telemed J E Health - The link between information and communication technologies and global public health: pushing forward. ( 0,561352250956467 )
J Biomed Inform - Summarization of clinical information: a conceptual model. ( 0,560795772801797 )
J Am Med Inform Assoc - The future state of clinical data capture and documentation: a report from AMIA's 2011 Policy Meeting. ( 0,559004788343454 )
Brief. Bioinformatics - Computational discrete models of tissue growth and regeneration. ( 0,557870989782793 )
J Clin Monit Comput - Translational applications of evaluating physiologic variability in human endotoxemia. ( 0,55699805782737 )
Comput Math Methods Med - Motion analysis of live objects by super-resolution fluorescence microscopy. ( 0,555213410227671 )
J Biomed Inform - Text mining for traditional Chinese medical knowledge discovery: a survey. ( 0,552255705309674 )
J Biomed Inform - Time motion studies in healthcare: what are we talking about? ( 0,552159264849394 )
Wiley Interdiscip Rev Syst Biol Med - Promise of personalized omics to precision medicine. ( 0,550776669538348 )
IEEE Trans Image Process - Discovering thematic objects in image collections and videos. ( 0,550155960756893 )
J Biomed Inform - Biomedical text mining and its applications in cancer research. ( 0,549022432337799 )
Brief. Bioinformatics - Comparison of software packages for detecting differential expression in RNA-seq studies. ( 0,546930386546644 )
Brief. Bioinformatics - Modern bioinformatics meets traditional Chinese medicine. ( 0,544054151395643 )
J Am Med Inform Assoc - Recent trends in biomedical informatics: a study based on JAMIA articles. ( 0,542290195974871 )
J Biomed Inform - 'Big data', Hadoop and cloud computing in genomics. ( 0,540473152864954 )
Int J Med Robot - Review of MRI positioning devices for guiding focused ultrasound systems. ( 0,539660153441488 )
Artif Intell Med - Smart wearable systems: current status and future challenges. ( 0,538648468476054 )
Med Biol Eng Comput - Quantitative calculation of human melatonin suppression induced by inappropriate light at night. ( 0,53672046788762 )
Brief. Bioinformatics - The what, where, how and why of gene ontology--a primer for bioinformaticians. ( 0,536271488508682 )
Brief. Bioinformatics - Compressive biological sequence analysis and archival in the era of high-throughput sequencing technologies. ( 0,535883552847171 )
Brief. Bioinformatics - Machine learning approaches for the discovery of gene-gene interactions in disease data. ( 0,53500425649872 )
J Clin Monit Comput - Flow cytometry and laser scanning cytometry, a comparison of techniques. ( 0,534813592164866 )
Appl Clin Inform - Paradigm shift or annoying distraction: emerging implications of web 2.0 for clinical practice. ( 0,534012221731326 )
AMIA Annu Symp Proc - A survey of rural hospitals' perspectives on health information technology outsourcing. ( 0,533298149983868 )
Med Decis Making - An emerging field of research: challenges in pediatric decision making. ( 0,531898111736945 )
J. Med. Internet Res. - How current are leading evidence-based medical textbooks? An analytic survey of four online textbooks. ( 0,530101726860314 )
Telemed J E Health - Telehealth trends and the challenge for infrastructure. ( 0,529240219079439 )
J. Med. Internet Res. - Single-case experimental designs to evaluate novel technology-based health interventions. ( 0,529170156201767 )
IEEE Trans Image Process - Blur and illumination robust face recognition via set-theoretic characterization. ( 0,52911539004587 )
IEEE Trans Image Process - Fast localization of the optic disc using projection of image features. ( 0,529114860240791 )
J Am Med Inform Assoc - Development of an optical character recognition pipeline for handwritten form fields from an electronic health record. ( 0,528962758832517 )
Res Synth Methods - Methods for documenting systematic review searches: a discussion of common issues. ( 0,528301206546662 )
IEEE Trans Image Process - A novel video dataset for change detection benchmarking. ( 0,524429767460919 )
Methods Inf Med - Reporting of medical research costs. Improving transparency and reproducibility of medical research. ( 0,523976143228227 )
J Biomed Inform - Approaches to verb subcategorization for biomedicine. ( 0,521873868534349 )
Brief. Bioinformatics - A review of statistical methods for prediction of proteolytic cleavage. ( 0,519785113318351 )
BMC Med Inform Decis Mak - Semantic text mining support for lignocellulose research. ( 0,518581258289512 )
Wiley Interdiscip Rev Syst Biol Med - Computational systems biology of aging. ( 0,518142512606704 )
Appl Clin Inform - Health informatics for pediatric disaster preparedness planning. ( 0,516960869395182 )
Brief. Bioinformatics - Bioinformatics for personal genome interpretation. ( 0,515063044468095 )
Brief. Bioinformatics - Multiscale modeling of macromolecular biosystems. ( 0,514631947177513 )
Brief. Bioinformatics - Design and validation issues in RNA-seq experiments. ( 0,514275934319796 )
Comput Math Methods Med - Automated bone age assessment: motivation, taxonomies, and challenges. ( 0,513963159439243 )
BMC Med Inform Decis Mak - GenDrux: a biomedical literature search system to identify gene expression-based drug sensitivity in breast cancer. ( 0,513643721002022 )
Med Decis Making - Assessing personalized medicines in Australia: a national framework for reviewing codependent technologies. ( 0,512874766762272 )
J Chem Inf Model - Computational prediction of metabolism: sites, products, SAR, P450 enzyme dynamics, and mechanisms. ( 0,512744410710798 )
Brief. Bioinformatics - Towards more accurate prediction of ubiquitination sites: a comprehensive review of current methods, tools and features. ( 0,511890244854049 )
Comput. Biol. Med. - Accelerating in silico research with workflows: a lesson in Simplicity. ( 0,510256150908762 )
Comput Math Methods Med - Recent progress and future challenges in MR electric properties tomography. ( 0,508481341528189 )
Sci Data - Erratum: Genomes and phenomes of a population of outbred rats and its progenitors. ( 0,508481341528189 )
Artif Intell Med - Local binary patterns variants as texture descriptors for medical image analysis. ( 0,508387569133535 )
Brief. Bioinformatics - Flexible experimentation in the modeling and simulation framework JAMES II--implications for computational systems biology. ( 0,507784659039243 )
Brief. Bioinformatics - Protein inference: a review. ( 0,506321985718178 )
Appl Clin Inform - Measurement error in performance studies of health information technology: lessons from the management literature. ( 0,506305056372392 )
AMIA Annu Symp Proc - Evolution in clinical knowledge management strategy at Intermountain Healthcare. ( 0,504746644323077 )
Brief. Bioinformatics - Next-generation sequencing: a challenge to meet the increasing demand for training workshops in Australia. ( 0,503431334904103 )
Med Decis Making - Addressing adoption and research design decisions simultaneously: the role of value of sample information analysis. ( 0,502849758749081 )
AMIA Annu Symp Proc - TextHunter--A User Friendly Tool for Extracting Generic Concepts from Free Text in Clinical Research. ( 0,502309549921401 )