J Am Med Inform Assoc - Computer-aided diagnosis of pneumonia in patients with chronic obstructive pulmonary disease.

Tópicos

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Resumo

CKGROUND: Early diagnosis of pneumonia and discrimination between this disease and chronic obstructive pulmonary disease (COPD) exacerbations in patients with COPD are crucial for optimal clinical management and treatment.OBJECTIVES: To examine the use of computerized analysis of respiratory sounds, a hybrid system based on principal component analysis (PCA) and probabilistic neural networks (PNNs), to aid the detection of coexisting pneumonia in patients with COPD.METHODS AND MATERIALS: A convenience sample of 58 patients with COPD (25 patients hospitalized for community-acquired pneumonia and 33 owing to acute exacerbation of COPD) was studied. Auscultations were performed by the patients themselves on their suprasternal notch. Short-time Fourier transform analysis was used to extract features from the recorded respiratory sounds, PCA was selected for dimensionality reduction and a PNN was trained as classifier. 10-Fold cross-validation and receiver operating characteristic curve analysis were used to estimate the system performance.RESULTS: Based on the cross-validation results, a sensitivity and a specificity of 72% and 81.8%, respectively, were achieved in validation data. The operating point was selected to maximize the specificity and sensitivity pair in the training set.DISCUSSION: The results strongly suggest that electronic self-auscultation at a single location (suprasternal notch) can support diagnosis of pneumonia in patients with COPD.CONCLUSIONS: A simple, cost-effective method has been proposed to aid decision-making in areas with no radiological facilities available and in resource-constrained settings, and could have a great diagnostic impact on telemedicine applications.

Resumo Limpo

ckground earli diagnosi pneumonia discrimin diseas chronic obstruct pulmonari diseas copd exacerb patient copd crucial optim clinic manag treatmentobject examin use computer analysi respiratori sound hybrid system base princip compon analysi pca probabilist neural network pnns aid detect coexist pneumonia patient copdmethod materi conveni sampl patient copd patient hospit communityacquir pneumonia owe acut exacerb copd studi auscult perform patient suprastern notch shorttim fourier transform analysi use extract featur record respiratori sound pca select dimension reduct pnn train classifi fold crossvalid receiv oper characterist curv analysi use estim system performanceresult base crossvalid result sensit specif respect achiev valid data oper point select maxim specif sensit pair train setdiscuss result strong suggest electron selfauscult singl locat suprastern notch can support diagnosi pneumonia patient copdconclus simpl costeffect method propos aid decisionmak area radiolog facil avail resourceconstrain set great diagnost impact telemedicin applic

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