Tópico 74

Palavras

gene ( 2352 )
biolog ( 1181 )
express ( 1162 )
network ( 874 )
genet ( 750 )
pathway ( 685 )
diseas ( 559 )
regul ( 486 )
genom ( 479 )
cell ( 428 )
complex ( 411 )
interact ( 381 )
analysi ( 376 )
identifi ( 373 )
function ( 366 )
associ ( 365 )
regulatori ( 361 )
transcript ( 341 )
phenotyp ( 303 )
profil ( 302 )
mechan ( 302 )
integr ( 300 )
signal ( 276 )
understand ( 261 )
molecular ( 257 )
differenti ( 241 )
dataset ( 233 )
variant ( 212 )
recent ( 185 )
cellular ( 184 )
modul ( 183 )
involv ( 169 )
protein ( 164 )
approach ( 163 )
identif ( 159 )
metabol ( 155 )
highthroughput ( 154 )
human ( 134 )
cancer ( 125 )
candid ( 125 )
dna ( 125 )
infer ( 120 )
mani ( 114 )
under ( 108 )
enrich ( 106 )
relationship ( 105 )
multipl ( 99 )
target ( 96 )
discov ( 92 )
insight ( 85 )
bioinformat ( 85 )
discoveri ( 81 )
novel ( 72 )
advanc ( 72 )
known ( 71 )
marker ( 66 )
implic ( 63 )
hypothes ( 60 )
largescal ( 53 )
pair ( 45 )
overlap ( 44 )
alter ( 43 )
modif ( 42 )
respons ( 42 )
fundament ( 42 )
whole ( 41 )
factor ( 40 )
growth ( 39 )
moreov ( 38 )
modern ( 37 )
character ( 37 )
demonstr ( 31 )
organ ( 30 )
furthermor ( 28 )
whose ( 25 )
togeth ( 23 )
appli ( 23 )
literatur ( 22 )
cycl ( 22 )
near ( 21 )
topolog ( 18 )
aris ( 18 )
serv ( 17 )
level ( 16 )
classic ( 16 )
latter ( 15 )
heterogen ( 13 )
can ( 13 )
cover ( 13 )
suit ( 11 )
proven ( 11 )
look ( 10 )
also ( 10 )
uniqu ( 9 )
select ( 9 )
singl ( 9 )
high ( 9 )
among ( 9 )
usual ( 8 )
famili ( 8 )

Resumos

J. Comput. Biol. - Bioinformatics method to analyze the mechanism of pancreatic cancer disorder. ( 59 )
Artif Intell Med - Identifying regulatory relationships among genomic loci, biological pathways, and disease. ( 58 )
J Am Med Inform Assoc - Identifying disease genes and module biomarkers by differential interactions. ( 51 )
J Biomed Inform - Protein interaction network underpins concordant prognosis among heterogeneous breast cancer signatures. ( 50 )
Artif Intell Med - An extensive analysis of disease-gene associations using network integration and fast kernel-based gene prioritization methods. ( 49 )
J Am Med Inform Assoc - An integrated approach to identify causal network modules of complex diseases with application to colorectal cancer. ( 49 )
Artif Intell Med - Self-focusing therapeutic gene delivery with intelligent gene vector swarms: intra-swarm signalling through receptor transgene expression in targeted cells. ( 48 )
J Integr Bioinform - Knowledge enrichment analysis for human tissue-specific genes uncover new biological insights. ( 47 )
J Am Med Inform Assoc - Extracting coordinated patterns of DNA methylation and gene expression in ovarian cancer. ( 46 )
Int J Med Inform - Translating genome wide association study results to associations among common diseases: in silico study with an electronic medical record. ( 45 )
J. Comput. Biol. - A topology-based score for pathway enrichment. ( 45 )
Methods Inf Med - Pathway based microarray analysis, utilising enzyme compounds and cascade events. ( 45 )
J Am Med Inform Assoc - Knowledge boosting: a graph-based integration approach with multi-omics data and genomic knowledge for cancer clinical outcome prediction. ( 44 )
J Integr Bioinform - An integrative bioinformatics framework for genome-scale multiple level network reconstruction of rice. ( 44 )
Wiley Interdiscip Rev Syst Biol Med - miRNA regulation in the context of functional protein networks: principles and applications. ( 44 )
Brief. Bioinformatics - Revealing the architecture of genetic and epigenetic regulation: a maximum likelihood model. ( 43 )
J. Comput. Biol. - Vavien: an algorithm for prioritizing candidate disease genes based on topological similarity of proteins in interaction networks. ( 42 )
Wiley Interdiscip Rev Syst Biol Med - Diverse functional networks of Tbx3 in development and disease. ( 42 )
Comput Biol Chem - In silico analysis of cis-acting regulatory elements in 5' regulatory regions of sucrose transporter gene families in rice (Oryza sativa Japonica) and Arabidopsis thaliana. ( 40 )
Comput. Biol. Med. - Identification and analysis of the regulatory network of Myc and microRNAs from high-throughput experimental data. ( 40 )
J Am Med Inform Assoc - Network models of genome-wide association studies uncover the topological centrality of protein interactions in complex diseases. ( 39 )
J Integr Bioinform - Assembling cell context-specific gene sets: a case in cardiomyopathy. ( 39 )
Wiley Interdiscip Rev Syst Biol Med - Bioimage informatics for understanding spatiotemporal dynamics of cellular processes. ( 39 )
J Biomed Inform - Comparative analysis of a novel disease phenotype network based on clinical manifestations. ( 38 )
Methods Inf Med - Identification of breast cancer prognosis markers using integrative sparse boosting. ( 38 )
J Integr Bioinform - Network expansion and pathway enrichment analysis towards biologically significant findings from microarrays. ( 37 )
Brief. Bioinformatics - Apoptosis regulatory protein-protein interaction demonstrates hierarchical scale-free fractal network. ( 36 )
J Integr Bioinform - Towards prediction and prioritization of disease genes by the modularity of human phenome-genome assembled network. ( 36 )
J. Comput. Biol. - An efficient data assimilation schema for restoration and extension of gene regulatory networks using time-course observation data. ( 36 )
Wiley Interdiscip Rev Syst Biol Med - Recent advances in prostate development and links to prostatic diseases. ( 36 )
Wiley Interdiscip Rev Syst Biol Med - Systems biology of adipose tissue metabolism: regulation of growth, signaling and inflammation. ( 36 )
Comput Biol Chem - Identifying novel prostate cancer associated pathways based on integrative microarray data analysis. ( 35 )
Artif Intell Med - Hybrid genetic algorithm-neural network: feature extraction for unpreprocessed microarray data. ( 35 )
Comput Biol Chem - Disruption of murine Tcte3-3 induces tissue specific apoptosis via co-expression of Anxa5 and Pebp1. ( 35 )
Comput. Biol. Med. - Computational gene network study on antibiotic resistance genes of Acinetobacter baumannii. ( 35 )
J Biomed Inform - Finding disease similarity based on implicit semantic similarity. ( 35 )
J Biomed Inform - Gene-disease association with literature based enrichment. ( 35 )
J. Comput. Biol. - Gene expression complex networks: synthesis, identification, and analysis. ( 35 )
Artif Intell Med - Pathway-based identification of a smoking associated 6-gene signature predictive of lung cancer risk and survival. ( 34 )
J Biomed Inform - A comparative study of covariance selection models for the inference of gene regulatory networks. ( 34 )
J. Comput. Biol. - Markov logic networks in the analysis of genetic data. ( 34 )
Wiley Interdiscip Rev Syst Biol Med - Genome network medicine: innovation to overcome huge challenges in cancer therapy. ( 34 )
Comput Math Methods Med - Integrating gene expression and protein interaction data for signaling pathway prediction of Alzheimer's disease. ( 33 )
Comput Math Methods Med - First comprehensive in silico analysis of the functional and structural consequences of SNPs in human GalNAc-T1 gene. ( 33 )
Wiley Interdiscip Rev Syst Biol Med - Sex and the circuitry: progress toward a systems-level understanding of vertebrate sex determination. ( 33 )
Comput Biol Chem - Hierarchical closeness efficiently predicts disease genes in a directed signaling network. ( 32 )
J Biomed Inform - Incorporating personalized gene sequence variants, molecular genetics knowledge, and health knowledge into an EHR prototype based on the Continuity of Care Record standard. ( 32 )
J. Comput. Biol. - An algorithm for efficient identification of branched metabolic pathways. ( 32 )
Wiley Interdiscip Rev Syst Biol Med - The adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation. ( 32 )
Brief. Bioinformatics - Combining multidimensional genomic measurements for predicting cancer prognosis: observations from TCGA. ( 31 )
Artif Intell Med - Multi-way association extraction and visualization from biological text documents using hyper-graphs: applications to genetic association studies for diseases. ( 31 )
Brief. Bioinformatics - Towards a comprehensive picture of the genetic landscape of complex traits. ( 31 )
IEEE J Biomed Health Inform - Using evolutional properties of gene networks in understanding survival prognosis of glioblastoma. ( 31 )
J Am Med Inform Assoc - Complex-disease networks of trait-associated single-nucleotide polymorphisms (SNPs) unveiled by information theory. ( 31 )
J Biomed Inform - Gene pathways and subnetworks distinguish between major glioma subtypes and elucidate potential underlying biology. ( 31 )
J. Comput. Biol. - Biological cluster evaluation for gene function prediction. ( 31 )
Comput Biol Chem - Bioinformatic analysis of molecular network of glucosinolate biosynthesis. ( 30 )
Comput. Biol. Med. - Degrees of separation as a statistical tool for evaluating candidate genes. ( 30 )
Comput Math Methods Med - Identification and functional annotation of genome-wide ER-regulated genes in breast cancer based on ChIP-Seq data. ( 30 )
J Biomed Inform - The detection of risk pathways, regulated by miRNAs, via the integration of sample-matched miRNA-mRNA profiles and pathway structure. ( 30 )
J Biomed Inform - A simulation to analyze feature selection methods utilizing gene ontology for gene expression classification. ( 30 )
J Biomed Inform - Independent component analysis: mining microarray data for fundamental human gene expression modules. ( 30 )
Comput Biol Chem - Improving the prediction of chemotherapeutic sensitivity of tumors in breast cancer via optimizing the selection of candidate genes. ( 29 )
Comput Biol Chem - Deciphering histone code of transcriptional regulation in malaria parasites by large-scale data mining. ( 29 )
J Biomed Inform - Inferring cell cycle feedback regulation from gene expression data. ( 29 )
Comput Biol Chem - Large-scale mining co-expressed genes in Arabidopsis anther: from pair to group. ( 28 )
Comput Biol Chem - Statistical analysis of combinatorial transcriptional regulatory motifs in human intron-containing promoter sequences. ( 28 )
Comput. Biol. Med. - A review on the computational approaches for gene regulatory network construction. ( 28 )
Comput. Biol. Med. - Network-based approach reveals Y chromosome influences prostate cancer susceptibility. ( 28 )
Comput. Biol. Med. - Discovering the transcriptional modules using microarray data by penalized matrix decomposition. ( 28 )
IEEE J Biomed Health Inform - Exploring robust diagnostic signatures for cutaneous melanoma utilizing genetic and imaging data. ( 28 )
J Biomed Inform - Prioritization of potential candidate disease genes by topological similarity of protein-protein interaction network and phenotype data. ( 28 )
J Biomed Inform - The inference of breast cancer metastasis through gene regulatory networks. ( 28 )
Comput Biol Chem - Using volcano plots and regularized-chi statistics in genetic association studies. ( 27 )
BMC Med Inform Decis Mak - Finding type 2 diabetes causal single nucleotide polymorphism combinations and functional modules from genome-wide association data. ( 27 )
Brief. Bioinformatics - Evolution of gene regulation--on the road towards computational inferences. ( 27 )
J Biomed Inform - Serum cancer biomarker discovery through analysis of gene expression data sets across multiple tumor and normal tissues. ( 27 )
J Chem Inf Model - Using molecular features of xenobiotics to predict hepatic gene expression response. ( 27 )
Wiley Interdiscip Rev Syst Biol Med - Using variability in gene expression as a tool for studying gene regulation. ( 27 )
AMIA Annu Symp Proc - Mining disease fingerprints from within genetic pathways. ( 26 )
Comput Biol Chem - Global expression analysis of miRNA gene cluster and family based on isomiRs from deep sequencing data. ( 26 )
Comput Biol Chem - Meta-analysis of microarray data: The case of imatinib resistance in chronic myelogenous leukemia. ( 26 )
Comput Math Methods Med - Understanding the pathogenesis of Kawasaki disease by network and pathway analysis. ( 26 )
J Chem Inf Model - Modular architecture of metabolic pathways revealed by conserved sequences of reactions. ( 26 )
J Biomed Inform - Data driven linear algebraic methods for analysis of molecular pathways: application to disease progression in shock/trauma. ( 26 )
J Integr Bioinform - Construction of coffee transcriptome networks based on gene annotation semantics. ( 26 )
Wiley Interdiscip Rev Syst Biol Med - Signaling networks in palate development. ( 26 )
Artif Intell Med - Detecting disease genes based on semi-supervised learning and protein-protein interaction networks. ( 25 )
Brief. Bioinformatics - Learning transcriptional regulation on a genome scale: a theoretical analysis based on gene expression data. ( 25 )
Brief. Bioinformatics - Principal component analysis based methods in bioinformatics studies. ( 25 )
Comput. Biol. Med. - A molecular prospective provides new insights into implication of PDYN and OPRK1 genes in alcohol dependence. ( 25 )
Comput. Biol. Med. - Revealing pathway maps of renal cell carcinoma by gene expression change. ( 25 )
J Am Med Inform Assoc - Integrated morphologic analysis for the identification and characterization of disease subtypes. ( 25 )
J Integr Bioinform - Profiling of genetic switches using boolean implications in expression data. ( 25 )
J Integr Bioinform - Computer and statistical analysis of transcription factor binding and chromatin modifications by ChIP-seq data in embryonic stem cell. ( 25 )
J. Comput. Biol. - Computational disease gene prioritization: an appraisal. ( 25 )
Wiley Interdiscip Rev Syst Biol Med - Regulatory variation: an emerging vantage point for cancer biology. ( 25 )
Wiley Interdiscip Rev Syst Biol Med - Establishing the stem cell state: insights from regulatory network analysis of blood stem cell development. ( 25 )
Comput Biol Chem - Revealing weak differential gene expressions and their reproducible functions associated with breast cancer metastasis. ( 24 )
Brief. Bioinformatics - Literature-aided interpretation of gene expression data with the weighted global test. ( 24 )