Tópico 90

Palavras

drug ( 1928 )
target ( 777 )
effect ( 648 )
potenti ( 617 )
product ( 542 )
reaction ( 478 )
identifi ( 446 )
interact ( 431 )
metabol ( 359 )
side ( 342 )
advers ( 339 )
new ( 334 )
resist ( 328 )
therapeut ( 300 )
profil ( 277 )
known ( 252 )
human ( 247 )
pair ( 244 )
associ ( 242 )
predict ( 241 )
indic ( 234 )
combin ( 216 )
develop ( 208 )
possibl ( 201 )
link ( 188 )
relationship ( 176 )
medicin ( 164 )
major ( 159 )
therefor ( 149 )
discoveri ( 148 )
also ( 139 )
respons ( 138 )
agent ( 138 )
efficaci ( 137 )
lead ( 137 )
well ( 126 )
pathway ( 124 )
uniqu ( 116 )
recent ( 115 )
essenti ( 109 )
comprehens ( 108 )
strategi ( 103 )
involv ( 103 )
novel ( 101 )
name ( 99 )
can ( 98 )
addit ( 93 )
caus ( 90 )
act ( 81 )
establish ( 76 )
among ( 74 )
abl ( 72 )
releas ( 70 )
complementari ( 68 )
top ( 60 )
treat ( 59 )
label ( 58 )
databas ( 57 )
modul ( 55 )
industri ( 55 )
packag ( 54 )
expect ( 54 )
knowledg ( 53 )
valuabl ( 49 )
mani ( 49 )
suggest ( 48 )
various ( 47 )
earli ( 47 )
enzym ( 44 )
serv ( 43 )
contain ( 41 )
necessari ( 40 )
either ( 40 )
desir ( 38 )
identif ( 37 )
like ( 37 )
occur ( 36 )
furthermor ( 34 )
appli ( 33 )
four ( 31 )
present ( 23 )
consequ ( 22 )
subsequ ( 21 )
togeth ( 21 )
now ( 20 )
help ( 20 )
rapid ( 19 )
import ( 19 )
number ( 18 )
magnitud ( 18 )
alway ( 18 )
compar ( 18 )
system ( 17 )
publish ( 16 )
candid ( 16 )
transform ( 15 )
right ( 15 )
analyt ( 15 )
built ( 15 )
distinct ( 15 )

Resumos

J. Med. Internet Res. - Packaging and labeling of pharmaceutical products obtained from the internet. ( 71 )
Methods Inf Med - Exploiting online discussions to discover unrecognized drug side effects. ( 51 )
J Am Med Inform Assoc - Drug side effect extraction from clinical narratives of psychiatry and psychology patients. ( 50 )
J Biomed Inform - Combining automatic table classification and relationship extraction in extracting anticancer drug-side effect pairs from full-text articles. ( 47 )
J Chem Inf Model - Prediction of polypharmacological profiles of drugs by the integration of chemical, side effect, and therapeutic space. ( 46 )
J Biomed Inform - Exploring the associations between drug side-effects and therapeutic indications. ( 44 )
Brief. Bioinformatics - The relationship between rational drug design and drug side effects. ( 43 )
BMC Med Inform Decis Mak - Designing concept maps for a precise and objective description of pharmaceutical innovations. ( 42 )
BMC Med Inform Decis Mak - Mining adverse drug reactions from online healthcare forums using hidden Markov model. ( 41 )
J Am Med Inform Assoc - A novel signal detection algorithm for identifying hidden drug-drug interactions in adverse event reports. ( 41 )
J Chem Inf Model - Network-based analysis and characterization of adverse drug-drug interactions. ( 40 )
J Biomed Inform - LabeledIn: cataloging labeled indications for human drugs. ( 38 )
Comput Biol Chem - Identification and characterization of potential drug targets by subtractive genome analyses of methicillin resistant Staphylococcus aureus. ( 36 )
J Chem Inf Model - Modular architecture of metabolic pathways revealed by conserved sequences of reactions. ( 35 )
AMIA Annu Symp Proc - Towards drug repositioning: a unified computational framework for integrating multiple aspects of drug similarity and disease similarity. ( 34 )
J Chem Inf Model - ReactionPredictor: prediction of complex chemical reactions at the mechanistic level using machine learning. ( 33 )
Int J Med Inform - Personal digital assistant with a barcode reader--a medical decision support system for nurses in home care. ( 32 )
J Biomed Inform - Kinase inhibition-related adverse events predicted from in vitro kinome and clinical trial data. ( 31 )
J Biomed Inform - Automatic signal extraction, prioritizing and filtering approaches in detecting post-marketing cardiovascular events associated with targeted cancer drugs from the FDA Adverse Event Reporting System (FAERS). ( 30 )
J. Med. Internet Res. - Postmarket drug surveillance without trial costs: discovery of adverse drug reactions through large-scale analysis of web search queries. ( 30 )
BMC Med Inform Decis Mak - Rule-based multi-scale simulation for drug effect pathway analysis. ( 29 )
Comput Biol Chem - Detecting breakdown points in metabolic networks. ( 29 )
J Am Med Inform Assoc - Drug-drug interaction through molecular structure similarity analysis. ( 29 )
J Chem Inf Model - Pathway analysis for drug repositioning based on public database mining. ( 29 )
Comput Biol Chem - Pharmacoepidemiological characterization of drug-induced adverse reaction clusters towards understanding of their mechanisms. ( 28 )
J Am Med Inform Assoc - Machine learning-based prediction of drug-drug interactions by integrating drug phenotypic, therapeutic, chemical, and genomic properties. ( 28 )
J Chem Inf Model - Characterizing binding of small molecules. II. Evaluating the potency of small molecules to combat resistance based on docking structures. ( 28 )
J Chem Inf Model - Computational study on the drug resistance mechanism against HCV NS3/4A protease inhibitors vaniprevir and MK-5172 by the combination use of molecular dynamics simulation, residue interaction network, and substrate envelope analysis. ( 28 )
Artif Intell Med - Discovering human immunodeficiency virus mutational pathways using temporal Bayesian networks. ( 27 )
Comput. Biol. Med. - Systems pharmacology-based approach for dissecting the addition and subtraction theory of traditional Chinese medicine: An example using Xiao-Chaihu-Decoction and Da-Chaihu-Decoction. ( 27 )
J Biomed Inform - A SNPshot of PubMed to associate genetic variants with drugs, diseases, and adverse reactions. ( 27 )
Comput. Biol. Med. - Identification of human drug targets using machine-learning algorithms. ( 26 )
J Am Med Inform Assoc - Toward creation of a cancer drug toxicity knowledge base: automatically extracting cancer drug-side effect relationships from the literature. ( 26 )
J. Med. Internet Res. - Building a transnational biosurveillance network using semantic web technologies: requirements, design, and preliminary evaluation. ( 26 )
J Chem Inf Model - Structural modeling of HCV NS3/4A serine protease drug-resistance mutations using end-point continuum solvation and side-chain flexibility calculations. ( 26 )
AMIA Annu Symp Proc - Exploring the relationship between drug side-effects and therapeutic indications. ( 25 )
Brief. Bioinformatics - Drug repositioning for orphan diseases. ( 25 )
J Biomed Inform - Disambiguation of PharmGKB drug-disease relations with NDF-RT and SPL. ( 25 )
J Chem Inf Model - Learning to predict chemical reactions. ( 25 )
Wiley Interdiscip Rev Syst Biol Med - Drug repurposing and adverse event prediction using high-throughput literature analysis. ( 25 )
Brief. Bioinformatics - Network-based drug discovery by integrating systems biology and computational technologies. ( 24 )
J Biomed Inform - Uncovering influence links in molecular knowledge networks to streamline personalized medicine. ( 24 )
J Chem Inf Model - Drug side-effect prediction based on the integration of chemical and biological spaces. ( 24 )
J Am Med Inform Assoc - Mining clinical text for signals of adverse drug-drug interactions. ( 23 )
J Biomed Inform - PREDOSE: a semantic web platform for drug abuse epidemiology using social media. ( 23 )
J Chem Inf Model - Chemogenomics approaches to rationalizing the mode-of-action of traditional Chinese and Ayurvedic medicines. ( 23 )
J. Med. Internet Res. - Online availability and safety of drugs in shortage: a descriptive study of internet vendor characteristics. ( 23 )
J Chem Inf Model - Classification of cytochrome P450 inhibitors and noninhibitors using combined classifiers. ( 23 )
J Clin Monit Comput - Perioperative metabolic alkalemia is more frequent than metabolic acidemia in major elective abdominal surgery. ( 23 )
Comput Biol Chem - Kernel-based data fusion improves the drug-protein interaction prediction. ( 22 )
J Biomed Inform - A comparison of machine learning techniques for detection of drug target articles. ( 22 )
J Chem Inf Model - Virtual affinity fingerprints for target fishing: a new application of Drug Profile Matching. ( 22 )
Brief. Bioinformatics - Database identifies FDA-approved drugs with potential to be repurposed for treatment of orphan diseases. ( 21 )
Comput Math Methods Med - Antibody Drug Conjugate bioinformatics: drug delivery through the letterbox. ( 21 )
Comput Methods Programs Biomed - Developing a data mining approach to investigate association between physician prescription and patient outcome - a study on re-hospitalization in Stevens-Johnson Syndrome. ( 21 )
J Chem Inf Model - Adverse drug events: database construction and in silico prediction. ( 21 )
J. Med. Internet Res. - The therapeutic relationship in e-therapy for mental health: a systematic review. ( 20 )
J Med Syst - A high-speed drug interaction search system for ease of use in the clinical environment. ( 20 )
J Chem Inf Model - Efficient a priori identification of drug resistant mutations using Dead-End Elimination and MM-PBSA. ( 20 )
Methods Inf Med - Design and evaluation of an ontology-based drug application database. ( 20 )
J Chem Inf Model - How do metabolites differ from their parent molecules and how are they excreted? ( 20 )
J Chem Inf Model - Theoretical studies on the susceptibility of oseltamivir against variants of 2009 A/H1N1 influenza neuraminidase. ( 20 )
J. Comput. Biol. - A genome-scale modeling approach to study inborn errors of liver metabolism: toward an in silico patient. ( 20 )
BMC Med Inform Decis Mak - A pipeline to extract drug-adverse event pairs from multiple data sources. ( 19 )
AMIA Annu Symp Proc - Predicting adverse drug events from personal health messages. ( 19 )
Int J Health Geogr - Pathways of neighbourhood-level socio-economic determinants of adverse birth outcomes. ( 19 )
Int J Med Inform - Computerized detection of adverse drug reactions in the medical intensive care unit. ( 19 )
J Biomed Inform - Identifying plausible adverse drug reactions using knowledge extracted from the literature. ( 19 )
J Biomed Inform - Using semantic predications to uncover drug-drug interactions in clinical data. ( 19 )
J Chem Inf Model - Insight into crizotinib resistance mechanisms caused by three mutations in ALK tyrosine kinase using free energy calculation approaches. ( 19 )
J Chem Inf Model - Identification of a new binding site in E. coli FabH using Molecular dynamics simulations: validation by computational alanine mutagenesis and docking studies. ( 19 )
Med Decis Making - US-Based Drug Cost Parameter Estimation for Economic Evaluations. ( 19 )
J. Comput. Biol. - Knowledge-based generalization of metabolic models. ( 19 )
J. Med. Internet Res. - Can online consumers contribute to drug knowledge? A mixed-methods comparison of consumer-generated and professionally controlled psychotropic medication information on the internet. ( 19 )
Comput Biol Chem - Predicting essential genes for identifying potential drug targets in Aspergillus fumigatus. ( 18 )
Int J Med Inform - The effect of an interactive e-drug calculations package on nursing students' drug calculation ability and self-efficacy. ( 18 )
J Biomed Inform - Discovering discovery patterns with Predication-based Semantic Indexing. ( 18 )
Wiley Interdiscip Rev Syst Biol Med - Role of systems pharmacology in understanding drug adverse events. ( 18 )
J Chem Inf Model - Drug-disease association and drug-repositioning predictions in complex diseases using causal inference-probabilistic matrix factorization. ( 18 )
J Chem Inf Model - Accurate atom-mapping computation for biochemical reactions. ( 18 )
J Chem Inf Model - 2D SMARTCyp reactivity-based site of metabolism prediction for major drug-metabolizing cytochrome P450 enzymes. ( 18 )
J Chem Inf Model - Drug effect prediction by polypharmacology-based interaction profiling. ( 18 )
AMIA Annu Symp Proc - Automatic extraction of drug indications from FDA drug labels. ( 17 )
BMC Med Inform Decis Mak - Risk factors for adverse reactions from contrast agents for computed tomography. ( 17 )
Comput. Biol. Med. - An algorithm for rapid computational construction of metabolic networks: a cholesterol biosynthesis example. ( 17 )
Int J Med Inform - Planning and tracking chemotherapy production for cancer treatment: a performing and integrated solution. ( 17 )
J Am Med Inform Assoc - Determining molecular predictors of adverse drug reactions with causality analysis based on structure learning. ( 17 )
J Am Med Inform Assoc - Comparison and validation of genomic predictors for anticancer drug sensitivity. ( 17 )
J Am Med Inform Assoc - Extracting drug indication information from structured product labels using natural language processing. ( 17 )
J Chem Inf Model - Virtual libraries of tetrapyrrole macrocycles. Combinatorics, isomers, product distributions, and data mining. ( 17 )
J. Comput. Biol. - Analysis of metabolic evolution in bacteria using whole-genome metabolic models. ( 17 )
J. Med. Internet Res. - Patient-reported outcomes as a source of evidence in off-label prescribing: analysis of data from PatientsLikeMe. ( 17 )
Artif Intell Med - Predicting warfarin dosage from clinical data: a supervised learning approach. ( 16 )
AMIA Annu Symp Proc - Structured vs. unstructured: factors affecting adverse drug reaction documentation in an EMR repository. ( 16 )
Brief. Bioinformatics - Systems pharmacology in drug discovery and therapeutic insight for herbal medicines. ( 16 )
Brief. Bioinformatics - Data mining the human gut microbiota for therapeutic targets. ( 16 )
Comput. Biol. Med. - Revealing pharmacodynamics of medicinal plants using in silico approach: a case study with wet lab validation. ( 16 )
J Biomed Inform - Automatic construction of a large-scale and accurate drug-side-effect association knowledge base from biomedical literature. ( 16 )
J Am Med Inform Assoc - The pattern of name tokens in narrative clinical text and a comparison of five systems for redacting them. ( 16 )
J Am Med Inform Assoc - Evaluating standard terminologies for encoding allergy information. ( 16 )